Is Acetyl Octapeptide-3 safe in cosmetics?
Acetyl Octapeptide-3 has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
GOOD
Active Ingredient
Acetyl Octapeptide-3
Also known as: UNII-8K14HJF88S, Acetyl-glu-glu-met-gln-arg-arg-ala-asp-amide, Ac-glu-glu-met-gln-arg-arg-ala-asp-nh2
INCI: ACETYL OCTAPEPTIDE-3
Acetyl Octapeptide-3 (CAS 868844-74-0) is a cosmetic active ingredient functioning as Neurotransmitter-inhibiting octapeptide (SNAP-8). Extended SNAP-25 analogue. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 868844-74-0 →
Function
Neurotransmitter-inhibiting octapeptide (SNAP-8). Extended SNAP-25 analogue that targets the SNARE complex at the neuromuscular junction. Disrupts vesicle fusion with the neuronal membrane by competing for SNAP-25 binding sites, thereby inhibiting acetylcholine exocytosis and reducing muscle contraction at expression line sites.
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
(4S)-4-acetamido-5-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-carboxy-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]hex-5-enoic acid
InChIKey
QGGBBQJHVCVVKM-XOBYPWAZSA-N
SMILES
CC(C(=O)NC(CC(=O)O)C(=O)N)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCC(=O)N)NC(=O)C(CCSC)NC(=O)C(CCC(=O)O)NC(=C)C(CCC(=O)O)NC(=O)C
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No FDA or CIR restriction. No pre-market approval required under MoCRA for cosmetic peptides. CIR has not specifically reviewed Acetyl Octapeptide-3 as of this report.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Acetyl Octapeptide-3.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Humectant
Softener and conditioner
Editorial summary
Preliminary editorial summary for Acetyl Octapeptide-3 — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
neurotransmitter-inhibitor
snare-complex
snap-25-analogue
snap-8
acetylcholine-inhibitor
Known Synonyms
UNII-8K14HJF88S
Acetyl-glu-glu-met-gln-arg-arg-ala-asp-amide
Ac-glu-glu-met-gln-arg-arg-ala-asp-nh2
Chemical Function
Humectant
Softener and conditioner
Frequently Asked Questions
Is Acetyl Octapeptide-3 allowed in the EU?
Acetyl Octapeptide-3 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Acetyl Octapeptide-3 do in cosmetics?
Acetyl Octapeptide-3 functions as: Neurotransmitter-inhibiting octapeptide (SNAP-8). Extended SNAP-25 analogue that targets the SNARE complex at the neuromuscular junction. Disrupts vesicle fusion with the neuronal membrane by competing for SNAP-25 binding sites, thereby inhibiting acetylcholine exocytosis and reducing muscle contraction at expression line sites.. It is classified as a Active Ingredient in our database. CAS number: 868844-74-0.
Compliance Tools
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MoS Calculator
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