Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Acetyl Octapeptide-3 (SNAP-8) is a neurotransmitter-inhibiting peptide with presynaptic SNARE complex disruption mechanism. Clinically validated via hyaluronic acid microneedle patch delivery showing significant wrinkle reduction and improved skin elasticity. High molecular weight (1073.2 g/mol) severely limits passive topical penetration; advanced delivery systems (microneedles, nanoliposomes) required for efficacy. No EU or US regulatory restrictions.
Regulatory Flags
Frequently Asked Questions
Is Acetyl Octapeptide-3 safe in cosmetics?
Acetyl Octapeptide-3 (SNAP-8) is a neurotransmitter-inhibiting peptide with presynaptic SNARE complex disruption mechanism. Clinically validated via hyaluronic acid microneedle patch delivery showing significant wrinkle reduction and improved skin elasticity. High molecular weight (1073.2 g/mol) severely limits passive topical penetration; advanced delivery systems (microneedles, nanoliposomes) required for efficacy. No EU or US regulatory restrictions. The EU classifies Acetyl Octapeptide-3 as "permitted". Safety rating: GOOD.
Is Acetyl Octapeptide-3 allowed in the EU?
Acetyl Octapeptide-3 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Acetyl Octapeptide-3 do in cosmetics?
Acetyl Octapeptide-3 functions as: Neurotransmitter-inhibiting octapeptide (SNAP-8). Extended SNAP-25 analogue that targets the SNARE complex at the neuromuscular junction. Disrupts vesicle fusion with the neuronal membrane by competing for SNAP-25 binding sites, thereby inhibiting acetylcholine exocytosis and reducing muscle contraction at expression line sites.. It is classified as a Active Ingredient in our database. CAS number: 868844-74-0.
What is the Margin of Safety for Acetyl Octapeptide-3?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
Check Acetyl Octapeptide-3 compliance across multiple jurisdictions:
Related Ingredients
Is Acetyl Octapeptide-3 in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Acetyl Octapeptide-3 in your formulation.