Aminophylline

INCI: AMINOPHYLLINE

CAS Number
317-34-0
Function
Skin conditioning (used in anti-cellulite topicals); pharmacologically a bronchodilator/cardiotonic
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status prohibited
US Notes Prohibited โ€” listed on Health Canada's Cosmetic Ingredient Hotlist

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Pharmaceutical active (theophylline + ethylenediamine); ethylenediamine is a potent allergen; prohibited in Canada; cardiovascular side-effect risk with systemic absorption

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Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Aminophylline safe in cosmetics?

Pharmaceutical active (theophylline + ethylenediamine); ethylenediamine is a potent allergen; prohibited in Canada; cardiovascular side-effect risk with systemic absorption The EU classifies Aminophylline as "prohibited". Safety rating: POOR.

Is Aminophylline allowed in the EU?

Aminophylline EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Aminophylline do in cosmetics?

Aminophylline functions as: Skin conditioning (used in anti-cellulite topicals); pharmacologically a bronchodilator/cardiotonic. It is classified as a cosmetic ingredient in our database. CAS number: 317-34-0.

What is the Margin of Safety for Aminophylline?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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