Is Aminophylline safe in cosmetics?
Aminophylline has a safety rating of "POOR" in our database. EU status: prohibited. US status: prohibited.
POOR
Cosmetic Ingredient
Aminophylline
Also known as: 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd. with 1,2-ethanediamine (2:1), Theophylline, compd. with ethylenediamine (2:1), Ethylenediamine, compd. with theophylline (1:2), 1H-Purine-2,6-dione, 3,9-dihydro-1,3-dimethyl-, compd. with 1,2-ethanediamine (2:1)
INCI: AMINOPHYLLINE
Aminophylline (CAS 317-34-0) is a cosmetic cosmetic ingredient functioning as Skin conditioning (used in anti-cellulite topicals); pharmacologically a. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
Function
Skin conditioning (used in anti-cellulite topicals); pharmacologically a bronchodilator/cardiotonic
Editorial assessment
POOR
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
prohibited
US US Status
prohibited
US Notes
Prohibited — listed on Health Canada's Cosmetic Ingredient Hotlist
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Aminophylline.
Calculate MoS for your specific formulation with the MoS Calculator.
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
ASEAN Cosmetic Directive (II)
Ref: A1136
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CA | banned | - | - |
| ASEAN | banned | - | All cosmetic products prohibited |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Surfactant (surface active agent)
Editorial summary
Preliminary editorial summary for Aminophylline — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
potential-allergen
Known Synonyms
1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd. with 1,2-ethanediamine (2:1)
Theophylline, compd. with ethylenediamine (2:1)
Ethylenediamine, compd. with theophylline (1:2)
1H-Purine-2,6-dione, 3,9-dihydro-1,3-dimethyl-, compd. with 1,2-ethanediamine (2:1)
Chemical Function
Surfactant (surface active agent)
Softener and conditioner
Regulatory Lists
Canada; Personal care; Substances in PCP - Canada (4/2014)
pharmaceutical
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
AMINOPHYLLINE
ChEMBL ID
CHEMBL1370561
Max Phase
4
Adverse Event Associations
83
Frequently Asked Questions
Is Aminophylline allowed in the EU?
Aminophylline EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Aminophylline do in cosmetics?
Aminophylline functions as: Skin conditioning (used in anti-cellulite topicals); pharmacologically a bronchodilator/cardiotonic. It is classified as a cosmetic ingredient in our database. CAS number: 317-34-0.
Is Aminophylline used outside cosmetics?
Aminophylline also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Aminophylline compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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