Is Amyl Salicylate safe in cosmetics?
Amyl Salicylate has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted.
Amyl Salicylate
Also known as: Benzoic acid, 2-hydroxy-, pentyl ester, BRN 2577253, Caswell No. 049AA, EINECS 218-080-2, NSC 403668 (+9 more)
INCI: AMYL SALICYLATE
Amyl Salicylate (CAS 2050-08-0) is a cosmetic cosmetic ingredient functioning as Perfuming, Skin Conditioning. EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 2050-08-0 →
Auto-generated CPSR Part A draft with source citations
Function
Perfuming, Skin Conditioning
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
pentyl 2-hydroxybenzoate
InChIKey
RANVDUNFZBMTBK-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
CIR assessed salicylates as safe when formulated to avoid irritation and sun sensitivity
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Amyl Salicylate.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization Profile
Contact sensitization data for Amyl Salicylate based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
0.2%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis
IFRA Restricted
Source: EU 2023/1545; SCCS
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
6480 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [271] RIFM (1982): RIFM report number 1643, April 27, unpublished.
HRIPT Human Patch Test Studies
3 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 6750 | - | - |
| HMT | - | 0 | 6750 | - | - |
| HMT | - | 0 | 6480 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
No longer valid
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
2 property records from structured ingredient metadata.
allergen_detail
{"eu_allergen_listed": "yes", "allergen_class": "fragrance", "patch_test_frequency_pct": "0.2", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "yes", "source": "EU 2023/1545; SCCS"}
fragrance_ifra
{"cas_number": "2050-08-0", "ifra_amendment_number": "49", "ifra_restriction_type": "Restricted", "ifra_max_use_level_category_1_pct": "0.12", "ifra_max_use_level_category_4_pct": "1.9", "ifra_max_use_level_category_7_pct": "0.28", "ifra_max_use_level_category_11_pct": "0.055", "eu_allergen_declaration_required": "No", "eu_26_allergens_list": "No", "sccs_opinion_available": "Yes", "sensitization_p…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Softener and conditioner
Regulatory List Membership (4)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Amyl Salicylate.
Regulatory Flags
EU_RESTRICTED
ALLERGEN
epa_safer_alternative
ifra_fragrance
fda_food_additive
Known Synonyms
Benzoic acid, 2-hydroxy-, pentyl ester
BRN 2577253
Caswell No. 049AA
EINECS 218-080-2
NSC 403668
NSC 44877
NSC 46125
Pentyl salicylate
Amylester kyseliny salicylove
UNII-VZO9C30208
2-Hydroxybenzoic acid, pentyl ester
N-Amyl salicylate
Salicylic acid, amyl ester
Salicylic acid, pentyl ester
Chemical Function
Fragrance
Softener and conditioner
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
consumer_product
inert_ingredient; non_food_use; Pesticides
air; Cleaning products and household care - air freshener; detected; emissions; Europe
Europe
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Amyl Salicylate allowed in the EU?
Amyl Salicylate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Amyl Salicylate do in cosmetics?
Amyl Salicylate functions as: Perfuming, Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 2050-08-0.
Is Amyl Salicylate used outside cosmetics?
Amyl Salicylate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Amyl Salicylate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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