Good Fragrance Sensitization Data Dermal Penetration

Anise Alcohol

INCI: ANISE ALCOHOL

CAS Number
105-13-5
Function
Fragrance ingredient
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
high
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Sensitization Profile

Contact sensitization data for Anise Alcohol based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
0.3%
Cross-reactivity Group
fragrance-mix-II
Reaction Type
contact-dermatitis
IFRA Restricted โ€” max 1.0% in finished products

Source: ESSCA/IVDK

Dermal Penetration Profile

Skin absorption and penetration characteristics of Anise Alcohol, relevant to systemic exposure and MoS calculations.

Absorption %
18-28%
Penetration Level
epidermis
Penetration Depth
epidermis/dermis
Molecular Weight
138.2 Da
Log P
1.16
Systemic Absorption
yes
Topical Bioavailability
12-24%
Safety Margin Factor
high
Vehicle Dependent
Yes โ€” absorption varies by formulation

Source: SCCS/1459/11, IFRA

Expert Verdict

Good safety profile when used within IFRA fragrance limits; EU restriction applies with concentration limits per Annex III.

โš ๏ธ
Concern Level: Moderate

Regulatory Flags

EU Restricted Allergen eu_children_restricted ifra_fragrance fda_food_additive eu_cosing_listed

Frequently Asked Questions

Is Anise Alcohol safe in cosmetics?

Good safety profile when used within IFRA fragrance limits; EU restriction applies with concentration limits per Annex III. The EU classifies Anise Alcohol as "restricted". Safety rating: GOOD.

Is Anise Alcohol allowed in the EU?

Anise Alcohol EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Anise Alcohol do in cosmetics?

Anise Alcohol functions as: Fragrance ingredient. It is classified as a Fragrance in our database. CAS number: 105-13-5.

What is the Margin of Safety for Anise Alcohol?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

๐Ÿ“ฑ

Is Anise Alcohol in Your Products?

Scan any product label with Piro โ€” our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free โ†’

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Anise Alcohol in your formulation.