Is Anise Alcohol safe in cosmetics?
Anise Alcohol has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted.
Anise Alcohol
Also known as: 4-Methoxy benzenemethanol, p-Anisyl alcohol, 4-06-00-05909, Anisalcohol, p-, p-Anisol alcohol (+4 more)
INCI: ANISE ALCOHOL
Anise Alcohol (CAS 105-13-5) is a cosmetic fragrance functioning as Fragrance ingredient. EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
Cross-Vertical Regulatory Divergence
Anise Alcohol is classified GHS Danger (H302, H317, H318) in the chemicals database but is restricted in EU cosmetics.
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
Function
Fragrance ingredient
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
restricted
US US Status
permitted
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Anise Alcohol.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization Profile
Contact sensitization data for Anise Alcohol based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
0.3%
Cross-reactivity Group
fragrance-mix-II
Reaction Type
contact-dermatitis
IFRA Restricted
— max 1.0% in finished products
Source: ESSCA/IVDK
Dermal Penetration Profile
Skin absorption and penetration characteristics of Anise Alcohol, relevant to systemic exposure and MoS calculations.
Absorption %
18-28%
Penetration Level
epidermis
Penetration Depth
epidermis/dermis
Molecular Weight
138.2 Da
Log P
1.16
Systemic Absorption
yes
Topical Bioavailability
12-24%
Safety Margin Factor
high
Vehicle Dependent
Yes — absorption varies by formulation
Source: SCCS Opinion
EPA ToxValDB — Toxicity Values
6 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | =3000 mg/kg | Rabbit | dermal | - | ECHA |
| NOAEL | =20 mg/kg-day | Rat | oral | subchronic | EFSA |
| LD50 | =1780.8 mg/kg | Mouse | oral | - | ChemIDplus |
| LD50 | >11130 mg/kg | Mouse | dermal | - | ChemIDplus |
| LD50 | =3000 mg/kg | Rabbit | dermal | - | ChemIDplus |
| LD50 | =1335.6 mg/kg | Rat | oral | - | ChemIDplus |
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
7.1%
DPRA Lys %
3.2%
KeratinoSens IC50
2000 µM
hCLAT CV75
1000 µg/mL
LLNA EC3
7.1%
NESIL
3240 µg/cm²
LLNA: Moderate (1B)
GHS: 1B
Human: positive
Source: LLNA: P&G unpublished | Kern et al. (2010); DPRA: Otsubo et al., 2017; KS: No reference provided in NICEATM database; hCLAT: No reference provided in NICEATM database; HPPT: [143] Kligman AM (1971): Report to RIFM, 24 May, unpublished.
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 101 | 0 | 1771 | 1771 | non-sensitizer |
| HMT | - | 0 | 3240 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
BRIN Brazil/India Cosmetics
Brazil: Restricted (Fragrance Allergen) · max >0.001% leave-on / >0.01% rinse-off requires labeling
India: Restricted
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
No specific technical function
Regulatory List Membership (4)
EU Restricted for Children (Cosmetics)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
EU CosIng Cosmetics Ingredient Database
Editorial summary
Preliminary editorial summary for Anise Alcohol — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
EU Restricted
Allergen
eu_children_restricted
ifra_fragrance
fda_food_additive
eu_cosing_listed
Known Synonyms
4-Methoxy benzenemethanol
p-Anisyl alcohol
4-06-00-05909
Anisalcohol, p-
p-Anisol alcohol
BRN 0636654
EINECS 203-273-6
FEMA No. 2099
UNII-7N6XGV3U49
Chemical Function
Fragrance
No specific technical function
Regulatory Lists
Europe
Europe; Personal care; restricted
children; Europe; nondetect; Personal care
Europe; Personal care - deodorant
detected; Europe; Personal care - deodorant
detected; Europe; Personal care - deodorant
Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe
active_ingredient; Australia
Cleaning products and household care - air freshener; Cleaning products and household care - laundry and fabric treatment - fabric deodorizer; Europe; nondetect; Vehicle - car interior - auto air freshener
detected; Europe; Other direct contact consumer goods
consumer_product; detected; Europe
Australia; Food and drug - smoking-related products
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL294431
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
ANISYL ALCOHOL
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Anise Alcohol allowed in the EU?
Anise Alcohol EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Anise Alcohol do in cosmetics?
Anise Alcohol functions as: Fragrance ingredient. It is classified as a Fragrance in our database. CAS number: 105-13-5.
Is Anise Alcohol used outside cosmetics?
Anise Alcohol also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Anise Alcohol have different safety status in cosmetics vs industrial chemicals?
Anise Alcohol is classified GHS Danger (H302, H317, H318) in the chemicals database but is restricted in EU cosmetics.
Compliance Tools
Check Anise Alcohol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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