Excellent Fragrance NOAEL Data

Dihydromyrcenol

INCI: DIHYDROMYRCENOL

CAS Number
18479-58-8
Function
Fragrance; aroma chemical; fresh/clean note
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Cosmetic ingredient; no IFRA restrictions at standard use levels; GRAS flavor/fragrance status; iconic masculine fresh note since 1988

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

4 study endpoints found for Dihydromyrcenol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOEL 50 mg/kg bw/day oral rat oral REACH
NOAEL 1000 mg/kg bw/day oral rat oral REACH
NOAEL 500 mg/kg bw/day oral - oral REACH
NOAEL 1000 mg/kg bw/day oral - oral REACH

Expert Verdict

The defining aroma chemical of the modern masculine fresh/aquatic fragrance genre, responsible for the iconic clean-water note introduced with Davidoff Cool Water (1988). No IFRA restrictions at standard use levels; not an EU-listed allergen. Outstanding safety profile for a widely used fragrance ingredient.

โš ๏ธ
Concern Level: None

Regulatory Flags

fragrance aroma-chemical masculine-note fresh-aquatic no-ifra-restriction men-s-fragrance epa_safer_alternative ifra_fragrance

Frequently Asked Questions

Is Dihydromyrcenol safe in cosmetics?

The defining aroma chemical of the modern masculine fresh/aquatic fragrance genre, responsible for the iconic clean-water note introduced with Davidoff Cool Water (1988). No IFRA restrictions at standard use levels; not an EU-listed allergen. Outstanding safety profile for a widely used fragrance ingredient. The EU classifies Dihydromyrcenol as "permitted". Safety rating: EXCELLENT. 4 toxicological study endpoint(s) are available in our database.

Is Dihydromyrcenol allowed in the EU?

Dihydromyrcenol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Dihydromyrcenol do in cosmetics?

Dihydromyrcenol functions as: Fragrance; aroma chemical; fresh/clean note. It is classified as a Fragrance in our database. CAS number: 18479-58-8.

What is the Margin of Safety for Dihydromyrcenol?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Dihydromyrcenol?

The NOAEL (No Observed Adverse Effect Level) for Dihydromyrcenol is 50 mg/kg bw/day based on a oral study via oral route in rat. A total of 4 study endpoints are available. Source: REACH.

๐Ÿ“ฑ

Is Dihydromyrcenol in Your Products?

Scan any product label with Piro โ€” our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free โ†’

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Dihydromyrcenol in your formulation.