Is Hedione safe in cosmetics?
Hedione has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Fragrance
Hedione
Also known as: Methyl 3-oxo-2-pentyl-cyclopentaneacetate, Methyl (3-oxo-2-pentylcyclopentyl)acetate, EINECS 246-495-9, FEMA No. 3408, Kharismal (+3 more)
INCI: METHYL DIHYDROJASMONATE
Hedione (CAS 24851-98-7) is a cosmetic fragrance functioning as Perfuming, Fragrance Diffuser, Volume Enhancer. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 24851-98-7 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Hedione is classified GHS Danger (H301, H311, H314, H318, H330) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Perfuming, Fragrance Diffuser, Volume Enhancer
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
methyl 2-(3-oxo-2-pentylcyclopentyl)acetate
InChIKey
KVWWIYGFBYDJQC-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Used as fragrance component under RIFM/IFRA framework
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hedione.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
22.5%
DPRA Lys %
0%
KeratinoSens IC50
1729.547 µM
hCLAT CV75
500 µg/mL
NESIL
1500 µg/cm²
GHS: 1B
Human: positive
Source: DPRA: Cosmetics Europe; KS: Cosmetics Europe; hCLAT: Cosmetics Europe; HPPT: [152] Kligman AM (1976): Report to RIFM, 11 November, unpublished.
HRIPT Human Patch Test Studies
5 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 13500 | - | - |
| HRIPT | - | 0 | 1500.4 | - | - |
| HRIPT | - | 0 | 6200.01 | - | - |
| HRIPT | - | 0 | 11000 | - | - |
| HRIPT | - | 0 | 10000 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
1898
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
METHYL DIHYDROJASMONATE | 2010 | No safety concern at current levels of intake when used as a flavouring agent | TRS 960-JECFA 73/25 | FAS 64-JECFA 73/41
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Abrasive
Deodorizer
Flavouring and nutrient
Fragrance
Softener and conditioner
Regulatory List Membership (4)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Hedione.
Regulatory Flags
epa_safer_alternative
ifra_fragrance
fda_food_additive
Known Synonyms
Methyl 3-oxo-2-pentyl-cyclopentaneacetate
Methyl (3-oxo-2-pentylcyclopentyl)acetate
EINECS 246-495-9
FEMA No. 3408
Kharismal
Methyl (2-pentyl-3-oxocyclopentyl)acetate
UNII-3GW44CIE3Y
Cyclopentaneacetic acid, 3-oxo-2-pentyl-, methyl ester
Chemical Function
Fragrance
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
Europe
Cleaning products and household care - air freshener; Europe
artificial_sweat; detected; emissions; Europe; Toys and children's products
air; Cleaning products and household care - air freshener; detected; emissions; Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
DIHYDROJASMONIC ACID, METHYL ESTER
ChEMBL ID
CHEMBL1530328
Frequently Asked Questions
Is Hedione allowed in the EU?
Hedione EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hedione do in cosmetics?
Hedione functions as: Perfuming, Fragrance Diffuser, Volume Enhancer. It is classified as a Fragrance in our database. CAS number: 24851-98-7.
Is Hedione used outside cosmetics?
Hedione also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Hedione have different safety status in cosmetics vs industrial chemicals?
Hedione is classified GHS Danger (H301, H311, H314, H318, H330) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Hedione compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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Chemical family
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Perfuming
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