Is Iso E Super safe in cosmetics?
Iso E Super has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Fragrance
Iso E Super
Also known as: Ethanone, 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)-, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone, 1-(2,3,8,8-Tetramethyl-1,2,3,4,5,6,7,8-octahydro-2-naphthalenyl)ethanone, Iso-E Super, 2-Acetonaphthone, 1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl- (+8 more)
INCI: ISO E SUPER
Iso E Super (CAS 54464-57-2) is a cosmetic fragrance functioning as Fragrance; aroma chemical; woody/amber note. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 54464-57-2 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance; aroma chemical; woody/amber note
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
1-(2,3,8,8-tetramethyl-1,3,4,5,6,7-hexahydronaphthalen-2-yl)ethanone
InChIKey
FVUGZKDGWGKCFE-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Cosmetic fragrance ingredient; RIFM/IFRA safety assessment complete; used at varying concentrations in fine fragrance and personal care products; known for tenacity and skin amplification character
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Iso E Super.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
84.84%
DPRA Lys %
0.02%
KeratinoSens IC50
33.008 µM
hCLAT CV75
33.2 µg/mL
LLNA EC3
14.2%
NESIL
1240 µg/cm²
LLNA: Weak (1B)
GHS: 1B
Human: positive
Source: LLNA: RIFM (RIFM DB#51630) | RIFM (RIFM DB#55550); DPRA: Hoffmann et al., 2018; KS: Natsch et al. 2015 [DOI:10.1093/toxsci/kfu229]; hCLAT: No reference provided in NICEATM database; HPPT: [627] RIFM (1973): RIFM report number 19978, September 26, unpublished.
HRIPT Human Patch Test Studies
5 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 101 | 0 | 47244 | 47244 | non-sensitizer |
| HRIPT | - | 0 | 1550 | - | - |
| HRIPT | - | 0 | 1240 | - | - |
| HRIPT | - | 0 | - | - | - |
| HRIPT | - | 0 | 1377.78 | - | - |
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Cosmetic-Specific Mechanism
Category: fragrance
Receptor targets: ERα (weak)
LOEC: 10 µM
EU status: allowed (IFRA)
weak agonist
Additional Ingredient Properties
2 property records from structured ingredient metadata.
fragrance
{"cas_number": "54464-57-2", "ingredient_class": "aroma_chemical", "chemical_class": "other", "odor_family": "woody", "odor_description": "Woody, amber, cedar, velvety", "odor_strength": "strong", "odor_tenacity_hours": "180.0", "top_note": "no", "heart_note": "yes", "base_note": "yes", "blending_factor_1_10": "8.0", "threshold_of_detection_ppb": "30.0", "molecular_weight_Da": "234.38", "boiling_p…
fragrance_ifra
{"cas_number": "54464-57-2", "ifra_amendment_number": "49", "ifra_restriction_type": "Restricted", "ifra_max_use_level_category_1_pct": "0.17", "ifra_max_use_level_category_4_pct": "2.6", "ifra_max_use_level_category_7_pct": "0.40", "ifra_max_use_level_category_11_pct": "0.080", "eu_allergen_declaration_required": "No", "eu_26_allergens_list": "No", "sccs_opinion_available": "Yes", "sensitization_…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Fragrance
Regulatory List Membership (1)
IFRA Fragrance Transparency List
Expert Verdict
Expert safety assessment and concern-level summary for Iso E Super.
Regulatory Flags
fragrance
aroma-chemical
masculine-note
woody-amber
men-s-fragrance
rifm-reviewed
ifra_fragrance
Known Synonyms
Ethanone, 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)-
1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone
1-(2,3,8,8-Tetramethyl-1,2,3,4,5,6,7,8-octahydro-2-naphthalenyl)ethanone
Iso-E Super
2-Acetonaphthone, 1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-
Boisvelone
EINECS 259-174-3
1',2',3',4',5',6',7',8'-Octahydro-2',3',8',8'-tetramethyl-2'-acetonaphthone
1-(2,3,8,8-Tetramethyl-1,2,3,4,5,6,7,8-octahydronaphthalen-2-yl)ethanone
UNII-1GD7ODM28Y
Tetramethyl acetyloctahydronaphthalene
1-(2,3,8,8-Tetramethyl-1,2,3,4,5,6,7,8-octahydronaphthalen-2-yl)ethan-1-one
OTNE
Chemical Function
Fragrance
Regulatory Lists
IFRA Transparency
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1423553
Frequently Asked Questions
Is Iso E Super allowed in the EU?
Iso E Super EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Iso E Super do in cosmetics?
Iso E Super functions as: Fragrance; aroma chemical; woody/amber note. It is classified as a Fragrance in our database. CAS number: 54464-57-2.
Is Iso E Super used outside cosmetics?
Iso E Super also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Iso E Super compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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