Dibutyl Phthalate (DBP)
INCI: DIBUTYL PHTHALATE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Dibutyl Phthalate (DBP). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 152 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| LOAEL | 752 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| LOEL | 5000 ppm | oral | rat | oral | REACH |
| NOEL | ca.400 mg/kg bw/day | dermal | rat | dermal | REACH |
| NOEL | 5000 ppm | oral | mouse | oral | REACH |
| NOAEL | 152 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | ca.600 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 62.5 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | >=250 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 152 mg/kg bw/day | oral | rat | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
Expert Verdict
EU-banned CMR plasticizer since 2004. Confirmed reproductive and developmental toxin with endocrine-disrupting activity. Dermal penetration documented with detection in blood, breast milk, and umbilical cord blood confirming fetal exposure. US lacks federal restriction and relies on unreliable brand self-reporting. Recommend avoiding entirely; acetyl tributyl citrate (ATBC) is a safer replacement.
Regulatory Flags
Frequently Asked Questions
Is Dibutyl Phthalate (DBP) safe in cosmetics?
EU-banned CMR plasticizer since 2004. Confirmed reproductive and developmental toxin with endocrine-disrupting activity. Dermal penetration documented with detection in blood, breast milk, and umbilical cord blood confirming fetal exposure. US lacks federal restriction and relies on unreliable brand self-reporting. Recommend avoiding entirely; acetyl tributyl citrate (ATBC) is a safer replacement. The EU classifies Dibutyl Phthalate (DBP) as "prohibited". Safety rating: POOR. 10 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.
Is Dibutyl Phthalate (DBP) allowed in the EU?
Dibutyl Phthalate (DBP) EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Dibutyl Phthalate (DBP) do in cosmetics?
Dibutyl Phthalate (DBP) functions as: Plasticizer, film flexibility agent for nail polish. It is classified as a cosmetic ingredient in our database. CAS number: 84-74-2.
What is the Margin of Safety for Dibutyl Phthalate (DBP)?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Dibutyl Phthalate (DBP)?
The NOAEL (No Observed Adverse Effect Level) for Dibutyl Phthalate (DBP) is 152 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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