Is Bee Venom safe in cosmetics?
Bee Venom has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
MODERATE
Active Ingredient
Bee Venom
INCI: APIS MELLIFERA (BEE) VENOM
Bee Venom (CAS 8031-67-2) is a cosmetic active ingredient functioning as lip plumping agent, skin-conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical and food safety data.
Function
lip plumping agent, skin-conditioning
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FDA permits bee venom in cosmetics under FD&C Act provided product is safe under labeled conditions. Therapeutic claims (e.g., arthritis treatment) reclassify the product as a drug requiring FDA approval. No GRAS status (GRAS is food-only). FDA issued warning letter (Bee Delightful, Dec 2020) for unapproved drug claims. MoCRA PFAS/heavy metals provisions do not specifically target bee venom.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Bee Venom.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Editorial summary
Preliminary editorial summary for Bee Venom — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
no-sccs-opinion
no-cir-review
eu-permitted-no-annex
major-allergen
anaphylaxis-risk
neurotoxin-component
animal-derived
drug-claim-risk
Chemical Function
Softener and conditioner
Regulatory Lists
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA count match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Adverse Event Associations
8
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Royal jelly
Food Category
preservative
Frequently Asked Questions
Is Bee Venom allowed in the EU?
Bee Venom EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Bee Venom do in cosmetics?
Bee Venom functions as: lip plumping agent, skin-conditioning. It is classified as a Active Ingredient in our database. CAS number: 8031-67-2.
Is Bee Venom used outside cosmetics?
Bee Venom also appears in pharmaceutical and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Bee Venom compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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