Is Bischofite Magnesium Chloride safe in cosmetics?
Bischofite Magnesium Chloride has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Bischofite Magnesium Chloride
Also known as: Magnesium chloride anhydrous, Magnesium chloride (MgCl2), Caswell No. 531, DUS-top, EINECS 232-094-6 (+5 more)
INCI: MAGNESIUM CHLORIDE
Bischofite Magnesium Chloride (CAS 7786-30-3) is a cosmetic cosmetic ingredient functioning as viscosity controlling, antimicrobial, skin conditioning, astringent. NOAEL 1531 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted; GHS signal word WARNING. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 7786-30-3 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Bischofite Magnesium Chloride is classified GHS Danger (H290, H302, H315, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
viscosity controlling, antimicrobial, skin conditioning, astringent
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
magnesium dichloride
InChIKey
TWRXJAOTZQYOKJ-UHFFFAOYSA-L
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
GRAS affirmed by FDA (21 CFR 184.1426); widely used in personal care
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Bischofite Magnesium Chloride.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Bischofite Magnesium Chloride. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1840 mg/kg bw/day | oral | mouse | Carcinogenicity | COSMOS_DB |
| NOAEL | 3532 mg/kg bw/day | oral | mouse | Subchronic | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
WARNING
Hazard Statements
May be harmful if swallowed
Short-term Exposure Effects
The substance is mildly irritating to the eyes and respiratory tract.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Bischofite Magnesium Chloride across SCCS product categories, with measured dermal absorption where available.
EPA ToxValDB — Toxicity Values
10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LOEL | =0.00002 mmol | Rat | injection | acute | ECOTOX |
| LOEL | =46.4 mM | Rat | oral | short-term | ECOTOX |
| LOEL | =0.0046 mM | Rat | oral | short-term | ECOTOX |
| LOEL | =5 % | Mouse | oral | chronic | ECOTOX |
| LOEL | =5 % | Mouse | oral | chronic | ECOTOX |
| LOEL | =2.5 % | Mouse | oral | chronic | ECOTOX |
| NOEL | =2.5 % | Mouse | oral | chronic | ECOTOX |
| NOEL | =2.5 % | Mouse | oral | chronic | ECOTOX |
| NOEL | =1.25 % | Mouse | oral | chronic | ECOTOX |
| NOEL | <46.4 mM | Rat | oral | short-term | ECOTOX |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE; GROUP
SVHC Candidate
No
Additional Ingredient Properties
7 property records from structured ingredient metadata.
acne
{"cas_number": "7786-30-3", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "5-10", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction…
anti_aging
{"anti_aging_claim": "barrier-repair, anti-inflammatory", "mechanism_of_action": "Cofactor for enzymatic reactions, ionic balance", "target_skin_layer": "epidermis", "collagen_stimulation": "No", "elastin_protection": "No", "wrinkle_reduction_pct": "5-10", "clinical_study_duration_weeks": "8", "sample_size": "20", "double_blind": "No", "placebo_controlled": "Yes", "published_journal": "Trace eleme…
anti_pollution
{"cas_number": "7786-30-3", "ingredient_class": "other", "primary_mechanism": "barrier_reinforcement", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_kB_inhibiti…
concentration
{"min_concentration_pct": "0.5", "max_concentration_pct": "5.0", "typical_concentration_pct": "2.0", "product_type": "Moisturizer", "function_at_concentration": "Skin barrier, calming", "source": "Supplier TDS"}
cost_pricing
{"cost_tier": "budget", "estimated_cost_per_kg_usd_low": "3", "estimated_cost_per_kg_usd_high": "6", "natural_premium_markup_pct": "0", "organic_certified_premium_pct": "0", "supply_chain_volatility": "low", "primary_source_region": "Global", "bulk_discount_threshold_kg": "1000", "seasonal_price_variation": "low", "commodity_or_specialty": "commodity", "substitute_ingredients": "Dead Sea Salt", "c…
mineral_clay
{"cas_number": "7786-30-3", "ingredient_class": "magnesium_compound", "chemical_formula": "MgCl2", "mineral_origin": "natural", "particle_size_range_um": "10-500", "surface_area_m2_per_g": "0.5-3", "crystal_structure": "hexagonal", "color_appearance": "white", "opacity": "opaque", "refractive_index": "1.56", "oil_absorption_g_per_100g": "150-400", "water_absorption_capacity": "low", "surface_charg…
ph_stability
{"optimal_ph_min": "5.0", "optimal_ph_max": "9.0", "stable_ph_min": "4.5", "stable_ph_max": "10.0", "degrades_above_ph": "11.0", "degrades_below_ph": "4.0", "ph_dependent_function": "Mineral supplement", "formulation_note": "Relatively stable", "source": "Formulation literature"}
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
ICSC Safety Card
0764
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Regulatory (2)
JECFA Evaluation
MAGNESIUM CHLORIDE | 1979 | NOT LIMITED | Included in the ADI group for hydrochloric acid and bases | TRS 648-JECFA 23/30 | FAS 67.29/NMRS 40A,B,C/141 (1965; HYDROCHLORIC ACID)
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
EU Food Improvement
Food additives
Source: EU Food Improvement Agents
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Chemical reaction regulator
Dye
Filler
Flavouring and nutrient
Fragrance
No specific technical function
Preservative
Processing aids not otherwise specified
Stabilizing agent
Regulatory List Membership (5)
EU Regulated in Personal Care
EU Restricted for Children (Cosmetics)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Bischofite Magnesium Chloride.
Regulatory Flags
eu_children_restricted
epa_safer_alternative
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Bischofite Magnesium Chloride by CAS number or substance name.
Studies
2
Lowest NOAEL
1840 mg/kg bw/day
Highest NOAEL
3532 mg/kg bw/day
COSMOS_DB
Known Synonyms
Magnesium chloride anhydrous
Magnesium chloride (MgCl2)
Caswell No. 531
DUS-top
EINECS 232-094-6
EPA Pesticide Chemical Code 013902
UNII-59XN63C8VM
MgCl2
[MgCl2]
Magnesium chloride, anhydrous
Chemical Function
Viscosity modifier
Thickening agent
Biocide
No specific technical function
Processing aids not otherwise specified
Fragrance
Regulatory Lists
drinking_water; Europe; manufacturing; plastic_additive
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
inert_ingredient; Pesticides
inert_ingredient; non_food_use; Pesticides
inert_ingredient; non_food_use; Pesticides
active_ingredient; animal_products; Europe; pharmaceutical; residue
Europe; supplements
Europe; food_additive; supplements
children; Europe; Personal care
children; Europe; Personal care - general moisturizing - hand/body lotion
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
MAGNESIUM CHLORIDE ANHYDROUS
ChEMBL ID
CHEMBL2219642
Max Phase
4
Adverse Event Associations
618
Frequently Asked Questions
Is Bischofite Magnesium Chloride allowed in the EU?
Bischofite Magnesium Chloride EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Bischofite Magnesium Chloride do in cosmetics?
Bischofite Magnesium Chloride functions as: viscosity controlling, antimicrobial, skin conditioning, astringent. It is classified as a cosmetic ingredient in our database. CAS number: 7786-30-3.
What is the NOAEL for Bischofite Magnesium Chloride?
The NOAEL (No Observed Adverse Effect Level) for Bischofite Magnesium Chloride is 1840 mg/kg bw/day based on a Carcinogenicity study via oral route in mouse. A total of 2 study endpoints are available. Source: COSMOS_DB.
Is Bischofite Magnesium Chloride classified as hazardous under GHS?
Bischofite Magnesium Chloride carries a GHS signal word of "WARNING". Hazard statements: May be harmful if swallowed. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is Bischofite Magnesium Chloride used outside cosmetics?
Bischofite Magnesium Chloride also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Bischofite Magnesium Chloride have different safety status in cosmetics vs industrial chemicals?
Bischofite Magnesium Chloride is classified GHS Danger (H290, H302, H315, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Bischofite Magnesium Chloride compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Barium Sulfate Synth
Excellent
Same category
colorant, opacifying
Dicalcium Phosphate Dihydrate
Excellent
Same category
Abrasive, buffering, opacifying, oral...
Dihydrogen Phosphate
Excellent
Same category
Buffering, pH adjustment
Aluminum Sesquichlorohydrate
Good
Same category
Antiperspirant, Astringent, Deodorant
Kaolin Aluminum Hydroxide
Good
Same category
Opacifying, Emollient, Buffering
Kaolin Calcined
Good
Same category
Absorbent, opacifying, mattifying, bu...
1-Methylhydantoin-2-imide (Creatinine)
Excellent
Similar safety
Skin conditioning (skin brightening/l...
2,6-Dimethyl-7-octen-2-ol (Dihydromyrcenol)
Excellent
Similar safety
Fragrance (perfuming), masking
2-Ethoxy-2,6,6-Trimethyl-9-Methylenebicyclo[3.3.1]Nonane (Boisiris™)
Excellent
Similar safety
Fragrance (rich woody, orris/iris roo...
2-Hydroxypropylcarbamato Amodimethicone
Excellent
Similar safety
Hair conditioning; modified aminosili...
2-O-Ethyl Ascorbic Acid
Excellent
Similar safety
Softener and conditioner
3 O Ethyl Ascorbic Acid
Excellent
Similar safety
Antioxidant; tyrosinase inhibitor; me...
Magnesium Chloride
Moderate
Chemical family
Viscosity controlling, Flavouring, Fr...
NONADIENOL
Good
Chemical family
Perfuming
Vinyl Guaiacol
Moderate
Chemical family
Fragrance ingredient; masking agent
Is Bischofite Magnesium Chloride in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Bischofite Magnesium Chloride in your formulation.