Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Dihydrogen Phosphate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 250 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Inorganic dihydrogen phosphate anion used as pH buffer and chelating agent in cosmetics; appears in formulations as its sodium (NaH2PO4) or potassium (KH2PO4) salt; CIR-assessed as safe with no EU restrictions and excellent safety profile.
Regulatory Flags
Frequently Asked Questions
Is Dihydrogen Phosphate safe in cosmetics?
Inorganic dihydrogen phosphate anion used as pH buffer and chelating agent in cosmetics; appears in formulations as its sodium (NaH2PO4) or potassium (KH2PO4) salt; CIR-assessed as safe with no EU restrictions and excellent safety profile. The EU classifies Dihydrogen Phosphate as "permitted". Safety rating: EXCELLENT. 1 toxicological study endpoint(s) are available in our database.
Is Dihydrogen Phosphate allowed in the EU?
Dihydrogen Phosphate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dihydrogen Phosphate do in cosmetics?
Dihydrogen Phosphate functions as: Buffering, pH adjustment. It is classified as a cosmetic ingredient in our database. CAS number: 13598-36-2.
What is the Margin of Safety for Dihydrogen Phosphate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Dihydrogen Phosphate?
The NOAEL (No Observed Adverse Effect Level) for Dihydrogen Phosphate is 250 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.
Compliance Tools
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Related Ingredients
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