Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
7 study endpoints found for Calcium Disodium EDTA. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 250 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 250 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 250 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| NOAEL | 1340 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| dose_tested | 250 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| dose_tested | 250 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| dose_tested | 250 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
Expert Verdict
Chelating agent with excellent safety profile as used in cosmetics; poor environmental biodegradability and potential to remobilize heavy metals in aquatic sediments are concerns at higher concentrations well above typical cosmetic use levels.
Regulatory Flags
Frequently Asked Questions
Is Calcium Disodium EDTA safe in cosmetics?
Chelating agent with excellent safety profile as used in cosmetics; poor environmental biodegradability and potential to remobilize heavy metals in aquatic sediments are concerns at higher concentrations well above typical cosmetic use levels. The EU classifies Calcium Disodium EDTA as "permitted". Safety rating: EXCELLENT. 7 toxicological study endpoint(s) are available in our database.
Is Calcium Disodium EDTA allowed in the EU?
Calcium Disodium EDTA EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Calcium Disodium EDTA do in cosmetics?
Calcium Disodium EDTA functions as: Chelating agent — binds metal ions to protect formulation stability and appearance. It is classified as a cosmetic ingredient in our database. CAS number: 62-33-9.
What is the Margin of Safety for Calcium Disodium EDTA?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Calcium Disodium EDTA?
The NOAEL (No Observed Adverse Effect Level) for Calcium Disodium EDTA is 250 mg/kg bw/day based on a Carcinogenicity study via oral route in rat. A total of 7 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check Calcium Disodium EDTA compliance across multiple jurisdictions:
Related Ingredients
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