Is Calcium Disodium EDTA safe in cosmetics?
Calcium Disodium EDTA has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Calcium Disodium EDTA
Also known as: Calciate(2-), [[N,N'-1,2-ethanediylbis[N-[(carboxy-.kappa.O)methyl]glycinato-.kappa.N,.kappa.O]](4-)]-, disodium, (OC-6-21)-, Calciate(2-), [[N,N′-1,2-ethanediylbis[N-(carboxymethyl)glycinato]](4-)-N,N′,O,O′,ON,ON′]-, disodium, (OC-6-21)-, Calciate(2-), [(ethylenedinitrilo)tetraacetato]-, disodium, Acetic acid, (ethylenedinitrilo)tetra-, calcium disodium salt, Antalin (+15 more)
INCI: CALCIUM DISODIUM EDTA
Calcium Disodium EDTA (CAS 62-33-9) is a cosmetic cosmetic ingredient functioning as Chelating agent — binds metal ions to protect formulation stability and. NOAEL 250 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
Function
Chelating agent — binds metal ions to protect formulation stability and appearance
Editorial assessment
EXCELLENT
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
calcium;disodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate
InChIKey
SHWNNYZBHZIQQV-UHFFFAOYSA-J
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR: Safe as used — originally assessed 1998, reaffirmed 2019
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Calcium Disodium EDTA.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Calcium Disodium EDTA. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 250 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS DB |
| NOAEL | 1340 mg/kg bw/day | oral | rat | Developmental | COSMOS DB |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Calcium Disodium EDTA across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (1)
JECFA Evaluation
CALCIUM DISODIUM ETHYLENEDIAMINETETRAACETATE | 1973 | 0-2.5 mg/kg bw | As calcium disodium EDTA; no excess of disodium EDTA should remain in foods | NMRS 53/TRS 539-JECFA 17/18 | FAS 5/NMRS 53A-JECFA 17/173
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Biocide
Chelating agent
Dye
Flavouring and nutrient
Fragrance
Preservative
Processing aids not otherwise specified
Stabilizing agent
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Editorial summary
Preliminary editorial summary for Calcium Disodium EDTA — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Calcium Disodium EDTA by CAS number or substance name.
Studies
2
Lowest NOAEL
250 mg/kg bw/day
Highest NOAEL
1340 mg/kg bw/day
COSMOS DB
Known Synonyms
Calciate(2-), [[N,N'-1,2-ethanediylbis[N-[(carboxy-.kappa.O)methyl]glycinato-.kappa.N,.kappa.O]](4-)]-, disodium, (OC-6-21)-
Calciate(2-), [[N,N′-1,2-ethanediylbis[N-(carboxymethyl)glycinato]](4-)-N,N′,O,O′,ON,ON′]-, disodium, (OC-6-21)-
Calciate(2-), [(ethylenedinitrilo)tetraacetato]-, disodium
Acetic acid, (ethylenedinitrilo)tetra-, calcium disodium salt
Antalin
Calciate(2-), ((N,N'-1,2-ethanediylbis(N-(carboxymethyl)glycinato))(4-)-N,N',O,O',O(N),O(N'))-, disodium, (OC-6-21)-
Calciate(2-), ((N,N'-1,2-ethanediylbis(N-(carboxymethyl)glycinato))(4-)-N,N',O,O',ON,ON'), disodium, (OC-6-21)-
Calciedetate de sodium
Calcium disodium ethylendiaminetetraacetate
Calcium-EDTA
Chelaton
Dinatrium calcium edeticum
Disodium ((ethylenedinitrilo)tetraacetato)calciate
Edta,calcium
Edta,calcium disodium
Edta-calcium sodium
EINECS 200-529-9
Ethylenediaminetetraacetic acid, calcium disodium chelate
Ethylenediaminetetraacetic acid calcium disodium salt (1:1:2)
Ethylenediaminetetracetic acid calcium sodium salt (1:1:2)
Chemical Function
Chelating agent
Stabilizing agent
Preservative
Regulatory Lists
Canada; consumer_product; Substances in Products - Canada (4/2014)
inert_ingredient; non_food_use; Pesticides
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
inert_ingredient; Pesticides
pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
EDETATE CALCIUM DISODIUM ANHYDROUS
ChEMBL ID
CHEMBL1200375
Max Phase
4
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Calcium disodium EDTA
E Number
E385
ADI
2.5 mg/kg bw
Food Category
preservative
Frequently Asked Questions
Is Calcium Disodium EDTA allowed in the EU?
Calcium Disodium EDTA EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Calcium Disodium EDTA do in cosmetics?
Calcium Disodium EDTA functions as: Chelating agent — binds metal ions to protect formulation stability and appearance. It is classified as a cosmetic ingredient in our database. CAS number: 62-33-9.
What is the NOAEL for Calcium Disodium EDTA?
The NOAEL (No Observed Adverse Effect Level) for Calcium Disodium EDTA is 250 mg/kg bw/day based on a Carcinogenicity study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS DB.
Is Calcium Disodium EDTA used outside cosmetics?
Calcium Disodium EDTA also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Calcium Disodium EDTA compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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ANILINE
MODERATE
Chemical family
Not Reported
Calcium Acetate
GOOD
Chemical family
Masking, Viscosity Controlling
Phenacetin
POOR
Chemical family
Stabilizing agent
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