Good Active Ingredient SCCS/CIR Reviewed Dermal Penetration

Calendula Extract (Calendula Officinalis Flower Extract)

Also known as: Calendula officinalis flower extract, EINECS 283-949-5, Garden Marigold extracts

INCI: CALENDULA EXTRACT

Calendula Extract (Calendula Officinalis Flower Extract) (CAS 84776-23-8) is a cosmetic active ingredient functioning as Antioxidant. EU Regulation 1223/2009 status: permitted; 1 safety opinion reviewed (cir). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.

View industrial chemical safety profile for CAS 84776-23-8 →

Auto-generated CPSR Part A draft with source citations
CAS Number
84776-23-8
View industrial chemical safety profile →
Function
Antioxidant
Safety Rating
GOOD

Chemistry & Identifiers

EC Number
283-949-5
UNII: P0M7O4Y7YD Wikidata: Q72514983

Regulatory Status

EU EU Status permitted
US US Status permitted

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Calendula Extract (Calendula Officinalis Flower Extract).

Calculate MoS for your specific formulation with the MoS Calculator.

Safety Opinions

Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).

cir 7 January 2001
Verdict: unknown

Dermal Penetration Profile

Skin absorption and penetration characteristics of Calendula Extract (Calendula Officinalis Flower Extract), relevant to systemic exposure and MoS calculations.

Absorption %
2-5%
Penetration Level
surface
Penetration Depth
stratum corneum
Molecular Weight
Variable Da
Log P
n/a
Systemic Absorption
minimal
Topical Bioavailability
1-3%
Safety Margin Factor
low
Vehicle Dependent
Yes — absorption varies by formulation

Source: Phytother Res

ECHA REACH Registration

European Chemicals Agency REACH dossier and Substances of Very High Concern listing.

Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No

Additional Ingredient Properties

10 property records from structured ingredient metadata.

comedogenicity_detail
{"comedogenicity_rating": "0", "irritancy_rating": "0", "skin_type_suitability": "all,sensitive,combination,normal,rosacea", "acne_safe": "yes", "source": "Anti-inflammatory"}
concentration
{"min_concentration_pct": "0.5", "max_concentration_pct": "3.0", "typical_concentration_pct": "1.5", "product_type": "Healing Balm", "function_at_concentration": "Wound healing", "source": "Supplier TDS"}
cost_pricing
{"cost_tier": "budget", "estimated_cost_per_kg_usd_low": "18", "estimated_cost_per_kg_usd_high": "32", "natural_premium_markup_pct": "35", "organic_certified_premium_pct": "65", "supply_chain_volatility": "low", "primary_source_region": "Europe/Egypt", "synthetic_vs_natural_cost_ratio": "2.2", "bulk_discount_threshold_kg": "100", "seasonal_price_variation": "low", "commodity_or_specialty": "commod…
dermal_absorption
{"molecular_weight_da": "Variable", "skin_penetration_level": "surface", "penetration_depth": "stratum corneum", "absorption_pct": "2-5", "systemic_absorption": "minimal", "penetration_enhancer": "no", "occlusion_effect": "no", "vehicle_dependent": "yes", "skin_barrier_effect": "strengthens", "bioavailability_topical_pct": "1-3", "safety_margin_factor": "low", "source": "Phytother Res"}
ecotoxicity
{"biodegradable": "yes", "biodegradation_days": "28-60", "bioaccumulative": "no", "aquatic_toxicity_level": "low", "coral_reef_safe": "yes", "marine_toxicity": "very low toxicity", "freshwater_toxicity": "minimal impact", "endocrine_disruptor": "no", "persistent_organic_pollutant": "no", "microplastic": "no", "nano_particle": "no", "hawaii_banned": "no", "eu_restricted_environmental": "no", "palm_…
interactions
{"ingredient_2": "Panthenol", "interaction_type": "synergistic", "severity": "beneficial", "effect": "Soothing and healing, sensitive skin", "recommendation": "Compatible; gentle combination", "data_source": "Formulation science literature, dermatological research, cosmetic chemistry best practices", "last_updated": "2026-03-05"}
microbiome_impact
{"microbiome_effect": "positive", "prebiotic": "yes", "probiotic_compatible": "yes", "antimicrobial_spectrum": "selective", "preservative_effect_on_microbiome": "Wound healing; anti-inflammatory; supports beneficial bacteria", "gut_microbiome_risk": "low", "microbiome_recovery_time": "<3 days", "selective_antimicrobial": "yes", "beneficial_bacteria_support": "S. epidermidis, Lactobacillus spp", "p…
pediatric_safety
{"safe_for_newborn_0_6m": "yes", "safe_for_infant_6_12m": "yes", "safe_for_toddler_1_3y": "yes", "safe_for_child_3_12y": "yes", "safe_for_teen_12_18y": "yes", "pediatric_max_concentration_pct": "5.0", "adult_max_concentration_pct": "5.0", "pediatric_dermal_absorption_factor": "normal", "diaper_area_safe": "yes", "pediatric_allergy_prevalence": "low", "banned_in_children_products_eu": "no", "banned…

Function Categories & List Membership

Cosmetic/Chemical Function Categories
Biocide Deodorizer Flavouring and nutrient Fragrance Humectant Processing aids not otherwise specified Softener and conditioner
Regulatory List Membership (2)
EU Regulated in Personal Care EU Restricted for Children (Cosmetics)

Expert Verdict

Expert safety assessment and concern-level summary for Calendula Extract (Calendula Officinalis Flower Extract).

Regulatory Flags

eu_children_restricted

Known Synonyms

Calendula officinalis flower extract EINECS 283-949-5 Garden Marigold extracts

Chemical Function

Softener and conditioner Humectant Deodorizer Flavouring and nutrient

Regulatory Lists

Europe; Personal care children; Europe; Personal care children; Europe; Personal care - general moisturizing - hand/body lotion children; Europe; Personal care - specialized bath products - bubble bath children; Europe; Personal care - dental care - toothpaste Canada; Personal care; Substances in PCP - Canada (4/2014) Europe; Personal care Europe; Personal care Europe; Personal care

Australian Status

AICIS status: listed

Frequently Asked Questions

Is Calendula Extract (Calendula Officinalis Flower Extract) safe in cosmetics?

Calendula Extract (Calendula Officinalis Flower Extract) has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. This ingredient has been reviewed by cir.

Is Calendula Extract (Calendula Officinalis Flower Extract) allowed in the EU?

Calendula Extract (Calendula Officinalis Flower Extract) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Calendula Extract (Calendula Officinalis Flower Extract) do in cosmetics?

Calendula Extract (Calendula Officinalis Flower Extract) functions as: Antioxidant. It is classified as a Active Ingredient in our database. CAS number: 84776-23-8.

Is Calendula Extract (Calendula Officinalis Flower Extract) used outside cosmetics?

Calendula Extract (Calendula Officinalis Flower Extract) also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

Compliance Tools

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