Excellent Emollient NOAEL Data

Cetearyl Ethylhexanoate

INCI: CETEARYL ETHYLHEXANOATE

CAS Number
90411-68-0
Function
Ester of cetearyl alcohol (C16/C18 fatty alcohol) and 2-ethylhexanoic acid (branched C8). Light, non-greasy emollient with excellent skin feel. Branched-chain structure prevents crystalline packing, staying liquid at room temperature. Functions as emollient, skin-conditioning agent, and formulation aesthetic enhancer in premium leave-on and rinse-off products.
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes CIR reviewed and considered safe at current cosmetic use concentrations. Synthetically defined with excellent batch-to-batch consistency. Branched-chain 2-ethylhexanoate component confers oxidative stability. Non-greasy sensory profile makes it a premium choice in serums, sunscreens, and lightweight day creams.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
high
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Cetearyl Ethylhexanoate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL >=1000 mg/kg bw/day oral rat oral REACH
NOAEL >=1000 mg/kg bw/day oral - oral REACH

Expert Verdict

Premium light emollient ester with excellent sensory profile. Synthetically defined with superior batch consistency compared to natural oils. Branched-chain structure prevents crystallization and provides excellent oxidative stability. Well-tolerated with very low sensitization potential. Suitable for serums, sunscreens, and lightweight formulations.

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Concern Level: None

Regulatory Flags

premium-emollient light-sensory synthetically-defined non-greasy oxidatively-stable cir-assessed ifra_fragrance

Frequently Asked Questions

Is Cetearyl Ethylhexanoate safe in cosmetics?

Premium light emollient ester with excellent sensory profile. Synthetically defined with superior batch consistency compared to natural oils. Branched-chain structure prevents crystallization and provides excellent oxidative stability. Well-tolerated with very low sensitization potential. Suitable for serums, sunscreens, and lightweight formulations. The EU classifies Cetearyl Ethylhexanoate as "permitted". Safety rating: EXCELLENT. 2 toxicological study endpoint(s) are available in our database.

Is Cetearyl Ethylhexanoate allowed in the EU?

Cetearyl Ethylhexanoate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Cetearyl Ethylhexanoate do in cosmetics?

Cetearyl Ethylhexanoate functions as: Ester of cetearyl alcohol (C16/C18 fatty alcohol) and 2-ethylhexanoic acid (branched C8). Light, non-greasy emollient with excellent skin feel. Branched-chain structure prevents crystalline packing, staying liquid at room temperature. Functions as emollient, skin-conditioning agent, and formulation aesthetic enhancer in premium leave-on and rinse-off products.. It is classified as a Emollient in our database. CAS number: 90411-68-0.

What is the Margin of Safety for Cetearyl Ethylhexanoate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Cetearyl Ethylhexanoate?

The NOAEL (No Observed Adverse Effect Level) for Cetearyl Ethylhexanoate is >=1000 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.

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