Is Chamomilla Recutita Flower Extract safe in cosmetics?
Chamomilla Recutita Flower Extract has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 4 toxicological study endpoint(s) are available in our database.
Chamomilla Recutita Flower Extract
INCI: CHAMOMILLA RECUTITA FLOWER EXTRACT
Chamomilla Recutita Flower Extract (CAS 84082-60-0) is a cosmetic active ingredient functioning as Hydroethanolic or glycolic extract of Matricaria chamomilla (German chamomile). Reported NOAEL =200 mg/kg/d in rat (CIR_vision_codex); EU Regulation 1223/2009 status: permitted, max ≤0.5% leave-on. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 84082-60-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Chamomilla Recutita Flower Extract is classified GHS Danger (H304, H315, H317, H412) in the chemicals database but is allowed in EU cosmetics at max ≤0.5% leave-on.
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hydroethanolic or glycolic extract of Matricaria chamomilla (German chamomile) flowers. Principal actives: (-)-alpha-bisabolol (anti-inflammatory, wound healing, penetration enhancer) and chamazulene (anti-inflammatory, characteristic blue colour formed during steam distillation from matricine). Inhibits arachidonic acid-derived inflammatory mediators via 5-LOX and COX-1/2 suppression. Additional flavonoid content (apigenin, luteolin) contributes antioxidant and soothing activity. Widely used in sensitive-skin, atopic, and wound-healing formulations.
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
EU Max Conc.
≤0.5% leave-on
US US Status
permitted
US Notes
Permitted without restriction. Sesquiterpene lactone content (Compositae/Asteraceae family) relevant for cross-sensitization in confirmed composite-sensitive individuals. MoCRA safety substantiation required.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Chamomilla Recutita Flower Extract.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Chamomilla Recutita Flower Extract. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =200 mg/kg/d | oral | rat | oral toxicity | CIR_vision_codex |
| NOAEL | =200 mg/kg/d | oral | rat | oral toxicity | CIR_vision_codex |
| NOAEL | =200 mg/kg/d | oral | rat | oral toxicity | CIR_vision_codex |
| NOAEL | =200 mg/kg/d | oral | rat | oral toxicity | CIR_vision_codex |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Typical Use Concentrations
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Face Cream | 0.1–2 | 5 | CIR/VCRP |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "anti-inflammatory, antioxidant-protection", "mechanism_of_action": "Apigenin, bisabolol, soothing", "target_skin_layer": "epidermis", "collagen_stimulation": "No", "elastin_protection": "Mild", "wrinkle_reduction_pct": "2-6", "clinical_study_duration_weeks": "8", "sample_size": "30", "double_blind": "No", "placebo_controlled": "Yes", "published_journal": "Phytotherapy Researc…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Regulatory List Membership (2)
EU Regulated in Personal Care
EU Restricted for Children (Cosmetics)
Expert Verdict
Expert safety assessment and concern-level summary for Chamomilla Recutita Flower Extract.
Regulatory Flags
asteraceae-family
sensitizer-compositae-crossreaction
anti-inflammatory
soothing
wound-healing
bisabolol-source
chamazulene-source
eu_children_restricted
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Chamomilla Recutita Flower Extract by CAS number or substance name.
Studies
4
Lowest NOAEL
200 mg/kg/d
Highest NOAEL
200 mg/kg/d
CIR_vision_codex
Chemical Function
Deodorizer
Softener and conditioner
Fragrance
Regulatory Lists
children; Europe; Personal care
children; Europe; Personal care - hair styling and care - shampoo
children; Europe; Personal care - specialized bath products - bubble bath
children; Europe; Personal care - dental care - toothpaste
Europe; Personal care - hair styling and care - shampoo-dandruff
Europe; Personal care
Europe; Personal care
Europe; Personal care
Europe; Personal care
Europe; Personal care
Europe; Personal care
Europe; Personal care
Europe; Personal care
Europe; Personal care
Europe; Personal care
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA count match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Adverse Event Associations
58
Frequently Asked Questions
Is Chamomilla Recutita Flower Extract allowed in the EU?
Chamomilla Recutita Flower Extract EU regulatory status: permitted. Maximum allowed concentration: ≤0.5% leave-on. This is based on EU Regulation 1223/2009 and its amendments.
What does Chamomilla Recutita Flower Extract do in cosmetics?
Chamomilla Recutita Flower Extract functions as: Hydroethanolic or glycolic extract of Matricaria chamomilla (German chamomile) flowers. Principal actives: (-)-alpha-bisabolol (anti-inflammatory, wound healing, penetration enhancer) and chamazulene (anti-inflammatory, characteristic blue colour formed during steam distillation from matricine). Inhibits arachidonic acid-derived inflammatory mediators via 5-LOX and COX-1/2 suppression. Additional flavonoid content (apigenin, luteolin) contributes antioxidant and soothing activity. Widely used in sensitive-skin, atopic, and wound-healing formulations.. It is classified as a Active Ingredient in our database. CAS number: 84082-60-0.
What is the NOAEL for Chamomilla Recutita Flower Extract?
The NOAEL (No Observed Adverse Effect Level) for Chamomilla Recutita Flower Extract is =200 mg/kg/d based on a oral toxicity study via oral route in rat. A total of 4 study endpoints are available. Source: CIR_vision_codex.
Is Chamomilla Recutita Flower Extract used outside cosmetics?
Chamomilla Recutita Flower Extract also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Chamomilla Recutita Flower Extract have different safety status in cosmetics vs industrial chemicals?
Chamomilla Recutita Flower Extract is classified GHS Danger (H304, H315, H317, H412) in the chemicals database but is allowed in EU cosmetics at max ≤0.5% leave-on.
Compliance Tools
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MoS Calculator
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