Is Guanine safe in cosmetics?
Guanine has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Guanine
Also known as: EINECS 200-799-8, UNII-5Z93L87A1R, 2-Amino-1,9-dihydro-6H-purin-6-one, 2-Amino-1,9-dihydro-purin-6-one, 2-Amino-3,7-dihydro-6H-purin-6-one (+12 more)
INCI: GUANINE
Guanine (CAS 73-40-5) is a cosmetic cosmetic ingredient functioning as Opacifying agent; colorant (pearlescent/iridescent effect). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 73-40-5 →
Auto-generated CPSR Part A draft with source citations
Function
Opacifying agent; colorant (pearlescent/iridescent effect)
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
2-amino-1,7-dihydropurin-6-one
InChIKey
UYTPUPDQBNUYGX-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — permanently listed, exempt from certification; approved for cosmetics generally including eye area under 21 CFR 73.2329
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Guanine.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex IV — Permitted Colorants
Product type: White
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (IV - Colorants)
BRIN Brazil/India Cosmetics
India: Permitted Colorant
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| ASEAN | permitted_colorant | - | All products |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
colorant_formulator
{"ci_number": "77439", "ci_name": "Natural Pearl", "color_category": "white", "color_hex_code": "#F8F8FF", "natural_or_synthetic": "natural", "organic_or_inorganic": "organic", "lake_or_dye": "pigment", "fda_approved_use": "eye/general", "eu_approved_cosmetic": "yes", "japan_approved": "yes", "china_approved": "yes", "coverage_opacity": "transparent", "tinting_strength": "low", "lightfastness_rati…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Opacifer
Regulatory List Membership (2)
EU Regulated in Personal Care
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Guanine.
Regulatory Flags
potential-allergen
colorant
eu_cosing_listed
Known Synonyms
EINECS 200-799-8
UNII-5Z93L87A1R
2-Amino-1,9-dihydro-6H-purin-6-one
2-Amino-1,9-dihydro-purin-6-one
2-Amino-3,7-dihydro-6H-purin-6-one
2-Amino-6-purinol
2-Amino-Hypoxanthine
2-amino-6,7-dihydro-3H-purin-6-one
2-amino-6-oxopurine
6-Hydroxy-2-aminopurine
CI Natural white 1
GUN
Gua
Guanin
Mearlmaid
Naturon
Pathocidin
Chemical Function
Dye
Opacifer
Regulatory Lists
Europe; Personal care
pharmaceutical
Personal care
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
GUANINE
ChEMBL ID
CHEMBL219568
Max Phase
3
Frequently Asked Questions
Is Guanine allowed in the EU?
Guanine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Guanine do in cosmetics?
Guanine functions as: Opacifying agent; colorant (pearlescent/iridescent effect). It is classified as a cosmetic ingredient in our database. CAS number: 73-40-5.
Is Guanine used outside cosmetics?
Guanine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Guanine compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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