Is Isoleucine safe in cosmetics?
Isoleucine has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Isoleucine
INCI: ISOLEUCINE
Isoleucine (CAS 73-32-5 (L-Isoleucine)) is a cosmetic cosmetic ingredient functioning as Skin conditioning, hair conditioning, antistatic. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 73-32-5 (L-Isoleucine) →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning, hair conditioning, antistatic
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — GRAS as a nutrient supplement (21 CFR 172.320); no cosmetic-specific restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Isoleucine.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
2 property records from structured ingredient metadata.
acne
{"cas_number": "73-32-5", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-5", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction_ac…
anti_aging
{"anti_aging_claim": "barrier-repair", "mechanism_of_action": "Building block for proteins, NMF component", "target_skin_layer": "epidermis", "collagen_stimulation": "Mild", "elastin_protection": "Mild", "wrinkle_reduction_pct": "4-8", "clinical_study_duration_weeks": "8", "sample_size": "25", "double_blind": "No", "placebo_controlled": "Yes", "published_journal": "Int J Cosmet Sci", "improvement_…
Expert Verdict
Expert safety assessment and concern-level summary for Isoleucine.
Regulatory Flags
fda_food_additive
Frequently Asked Questions
Is Isoleucine allowed in the EU?
Isoleucine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Isoleucine do in cosmetics?
Isoleucine functions as: Skin conditioning, hair conditioning, antistatic. It is classified as a cosmetic ingredient in our database. CAS number: 73-32-5 (L-Isoleucine).
Compliance Tools
Check Isoleucine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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