Isoleucine

INCI: ISOLEUCINE

CAS Number
73-32-5 (L-Isoleucine)
Function
Skin conditioning, hair conditioning, antistatic
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” GRAS as a nutrient supplement (21 CFR 172.320); no cosmetic-specific restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Endogenous amino acid with well-established safety profile in food and pharmaceutical use; no safety concerns at cosmetic use levels.

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Concern Level: Low

Regulatory Flags

fda_food_additive

Frequently Asked Questions

Is Isoleucine safe in cosmetics?

Endogenous amino acid with well-established safety profile in food and pharmaceutical use; no safety concerns at cosmetic use levels. The EU classifies Isoleucine as "permitted". Safety rating: EXCELLENT.

Is Isoleucine allowed in the EU?

Isoleucine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Isoleucine do in cosmetics?

Isoleucine functions as: Skin conditioning, hair conditioning, antistatic. It is classified as a cosmetic ingredient in our database. CAS number: 73-32-5 (L-Isoleucine).

What is the Margin of Safety for Isoleucine?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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