Excellent Cosmetic Ingredient NOAEL Data

Citrus Aurantium Dulcis Peel Cera

INCI: CITRUS AURANTIUM DULCIS PEEL CERA

CAS Number
8028-48-6
Function
Skin-conditioning agent — emollient; film-forming agent
Safety Rating
EXCELLENT

Regulatory Status

🇪🇺 EU Status restricted
🇺🇸 US Status permitted
US Notes GRAS-derived; CIR-reviewed — safe in present practices of use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Citrus Aurantium Dulcis Peel Cera. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 5 mg/kg bw/day oral rat oral REACH
NOAEL 5 mg/kg bw/day oral - oral REACH
NOAEL 1000 mg/kg bw/day oral dog oral REACH
NOAEL 1000 mg/kg bw/day oral - oral REACH
NOAEL 600 mg/kg bw/day oral rat oral REACH
NOAEL 600 mg/kg bw/day oral - oral REACH
NOAEL 500 mg/kg bw/day oral mouse oral REACH
NOAEL 500 mg/kg bw/day oral - oral REACH
NOAEL 100 mg/kg bw/day oral dog oral REACH
NOAEL 100 mg/kg bw/day oral - oral REACH

Expert Verdict

Not phototoxic at 100% in human test; low concentrations of fragrance allergens present but below concern thresholds; verify heavy metals and pesticide residues per GMP

⚠️
Concern Level: Low

Regulatory Flags

potential-allergen ifra_fragrance

Frequently Asked Questions

Is Citrus Aurantium Dulcis Peel Cera safe in cosmetics?

Not phototoxic at 100% in human test; low concentrations of fragrance allergens present but below concern thresholds; verify heavy metals and pesticide residues per GMP The EU classifies Citrus Aurantium Dulcis Peel Cera as "restricted". Safety rating: EXCELLENT. 10 toxicological study endpoint(s) are available in our database.

Is Citrus Aurantium Dulcis Peel Cera allowed in the EU?

Citrus Aurantium Dulcis Peel Cera EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Citrus Aurantium Dulcis Peel Cera do in cosmetics?

Citrus Aurantium Dulcis Peel Cera functions as: Skin-conditioning agent — emollient; film-forming agent. It is classified as a cosmetic ingredient in our database. CAS number: 8028-48-6.

What is the Margin of Safety for Citrus Aurantium Dulcis Peel Cera?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Citrus Aurantium Dulcis Peel Cera?

The NOAEL (No Observed Adverse Effect Level) for Citrus Aurantium Dulcis Peel Cera is 5 mg/kg bw/day based on a oral study via oral route in rat. A total of 10 study endpoints are available. Source: REACH.

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