Is Poloxamer 407 safe in cosmetics?
Poloxamer 407 has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Surfactant
Poloxamer 407
Also known as: Polyoxyethylene-polyoxypropylene block copolymer, Oxirane, methyl-, polymer with oxirane, block, Propylene oxide ethylene oxide block polymer, Propylene oxide-ethylene oxide block copolymer, Propylene oxide-ethylene oxide blocker copolymer (+15 more)
INCI: POLOXAMER 407
Poloxamer 407 (CAS 106392-12-5) is a cosmetic surfactant functioning as Surfactant; solubilizer; micellar carrier. EU Regulation 1223/2009 status: permitted, max 7.5%. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 106392-12-5 →
Auto-generated CPSR Part A draft with source citations
Function
Surfactant; solubilizer; micellar carrier
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
2-methyloxirane;oxirane
InChIKey
RVGRUAULSDPKGF-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
EU Max Conc.
7.5%
US US Status
permitted
US Notes
Permitted; no concentration cap; used in ophthalmic formulations and contact lens solutions with strong ocular compatibility record
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Poloxamer 407.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Poloxamer 407.
Regulatory Flags
surfactant
micellar-water
eye-makeup-remover
eye-area
ophthalmic-compatible
contact-lens-safe
nonionic
well-tolerated
Known Synonyms
Polyoxyethylene-polyoxypropylene block copolymer
Oxirane, methyl-, polymer with oxirane, block
Propylene oxide ethylene oxide block polymer
Propylene oxide-ethylene oxide block copolymer
Propylene oxide-ethylene oxide blocker copolymer
Polyethylene glycol-polypropylene glycol block copolymer
Polyethylene oxide-polyypropylene oxide block copolymer
Pluronic PRE 1740
Poloxamer 401
Poloxamer 185
Kolliphor P 407
Lutrol 98
Synperonic F 78
Block polymer based on propylene oxide and ethylene oxide
PLURONIC F 68
Poloxamer P 123
Poloxamer P 85
Poloxamer L 61
Oxirane, 2-methyl-, polymer with oxirane, block
Poloxamer-188
Regulatory Lists
Canada; consumer_product; Substances in Products - Canada (4/2014)
inert_ingredient; non_food_use; Pesticides
Canada; Personal care; Substances in PCP - Canada (4/2014)
pharmaceutical
active_ingredient; animal_products; Europe; pharmaceutical; residue
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Poloxamer 407 allowed in the EU?
Poloxamer 407 EU regulatory status: permitted. Maximum allowed concentration: 7.5%. This is based on EU Regulation 1223/2009 and its amendments.
What does Poloxamer 407 do in cosmetics?
Poloxamer 407 functions as: Surfactant; solubilizer; micellar carrier. It is classified as a Surfactant in our database. CAS number: 106392-12-5.
Compliance Tools
Check Poloxamer 407 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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Not Reported
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