Excellent Surfactant

Poloxamer 407

INCI: POLOXAMER 407

CAS Number
106392-12-5
Function
Surfactant; solubilizer; micellar carrier
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
EU Max Conc. 7.5%
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted; no concentration cap; used in ophthalmic formulations and contact lens solutions with strong ocular compatibility record

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Block copolymer nonionic surfactant forming the micelle structure of micellar water eye makeup removers. Encapsulates makeup particles allowing gentle removal without aggressive rubbing. Exceptional ocular compatibility profile reinforced by its use in ophthalmic formulations and contact lens care solutions. Micellar water formulations with poloxamers provide an oil-free and alcohol-free removal option appropriate for contact lens wearers and sensitive periorbital skin. No regulatory restrictions for eye-area use in any major market.

โš ๏ธ
Concern Level: None

Regulatory Flags

surfactant micellar-water eye-makeup-remover eye-area ophthalmic-compatible contact-lens-safe nonionic well-tolerated

Frequently Asked Questions

Is Poloxamer 407 safe in cosmetics?

Block copolymer nonionic surfactant forming the micelle structure of micellar water eye makeup removers. Encapsulates makeup particles allowing gentle removal without aggressive rubbing. Exceptional ocular compatibility profile reinforced by its use in ophthalmic formulations and contact lens care solutions. Micellar water formulations with poloxamers provide an oil-free and alcohol-free removal option appropriate for contact lens wearers and sensitive periorbital skin. No regulatory restrictions for eye-area use in any major market. The EU classifies Poloxamer 407 as "permitted". Safety rating: EXCELLENT.

Is Poloxamer 407 allowed in the EU?

Poloxamer 407 EU regulatory status: permitted. Maximum allowed concentration: 7.5%. This is based on EU Regulation 1223/2009 and its amendments.

What does Poloxamer 407 do in cosmetics?

Poloxamer 407 functions as: Surfactant; solubilizer; micellar carrier. It is classified as a Surfactant in our database. CAS number: 106392-12-5.

What is the Margin of Safety for Poloxamer 407?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

๐Ÿ“ฑ

Is Poloxamer 407 in Your Products?

Scan any product label with Piro โ€” our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free โ†’

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Poloxamer 407 in your formulation.