Is Copper Tripeptide-1 safe in cosmetics?
Copper Tripeptide-1 has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Active Ingredient
Copper Tripeptide-1
Also known as: Kollaren, Glycyl-histidyl-lysine, Gly-his-lys, NSC 379527, UNII-39TG2H631E (+5 more)
INCI: COPPER TRIPEPTIDE-1
Copper Tripeptide-1 (CAS 49557-75-7) is a cosmetic active ingredient functioning as Bioactive copper peptide; stimulates collagen types I, III, and IV and elastin. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 49557-75-7 →
Auto-generated CPSR Part A draft with source citations
Function
Bioactive copper peptide; stimulates collagen types I, III, and IV and elastin synthesis; modulates matrix metalloproteinases (MMP balance); reduces inflammatory cytokines and oxidative stress markers; attracts immune cells to wound sites; restores fibroblast replicative vitality; emerging hair-growth stimulant
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No FDA restriction on copper tripeptide-1 as a cosmetic ingredient; used in OTC anti-aging serums. Nano copper regulation not applicable to peptide form.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Copper Tripeptide-1.
Calculate MoS for your specific formulation with the MoS Calculator.
Typical Use Concentrations
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Serum | 0.001–0.05 | 0.1 | Industry |
Additional Ingredient Properties
10 property records from structured ingredient metadata.
amino_acid
{"cas_number": "49557-75-7", "ingredient_class": "tripeptide", "source_origin": "synthetic", "molecular_weight_range_Da": "340", "amino_acid_composition_key": "GHK_copper_complex", "charge_at_pH_5_5": "cationic", "water_solubility": "soluble", "oil_solubility": "insoluble", "film_forming_ability": "poor", "moisture_binding_capacity": "moderate", "NMF_component": "no", "skin_penetration_depth": "de…
anti_pollution
{"cas_number": "89030-95-5", "ingredient_class": "antioxidant_pollution_shield", "primary_mechanism": "free_radical_scavenging", "pollution_types_targeted": "PM2_5/UV_A", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_mod…
baby_pediatric
{"cas_number": "49557-75-7/89030-95-5", "ingredient_class": "other", "pediatric_safety_rating": "avoid", "minimum_age_months": "24", "neonatal_safe": "no", "premature_infant_safe": "insufficient_data", "skin_barrier_maturity_consideration": "Copper peptide - adult", "transepidermal_absorption_risk_pediatric": "low", "systemic_exposure_concern_pediatric": "low", "dose_per_kg_body_weight_concern": "…
concentration
{"min_concentration_pct": "0.00001", "max_concentration_pct": "0.005", "typical_concentration_pct": "0.0005", "product_type": "Moisturizer", "function_at_concentration": "Skin repair", "source": "Clinical literature"}
ecotoxicity
{"biodegradable": "partial", "biodegradation_days": "90-180", "bioaccumulative": "yes", "aquatic_toxicity_level": "moderate", "coral_reef_safe": "unknown", "marine_toxicity": "copper toxicity concerns", "freshwater_toxicity": "metal accumulation", "endocrine_disruptor": "no", "persistent_organic_pollutant": "yes", "microplastic": "no", "nano_particle": "no", "hawaii_banned": "no", "eu_restricted_e…
peptide
{"cas_number": "49557-75-7", "trade_name": "GHK-Cu / Copper Peptide", "peptide_sequence_amino_acids": "Gly-His-Lys-Cu2+", "peptide_length_residues": "3", "molecular_weight_daltons": "340.4", "peptide_class": "signal/carrier", "mechanism_of_action": "Copper delivery, wound healing, collagen/elastin stimulation, antioxidant, anti-inflammatory, MMP inhibition", "target_protein_or_receptor": "TGF-beta…
regulatory
{"eu_status": "allowed", "us_status": "allowed"}
self_tanning
{"cas_number": "49557-75-7", "ingredient_class": "tan_accelerator", "tanning_mechanism": "melanin_stimulation", "color_development_onset_hours": "72.0", "full_color_development_hours": "240", "color_duration_days": "14", "color_depth": "light", "undertone": "natural", "DHA_concentration_if_applicable_pct": "0", "erythrulose_concentration_pct": "0", "pH_dependent_color": "no", "formaldehyde_release…
Expert Verdict
Expert safety assessment and concern-level summary for Copper Tripeptide-1.
Regulatory Flags
bioactive-peptide
collagen-booster
anti-aging
mmp-modulator
anti-inflammatory
hair-growth
copper-complex
stability-sensitive
penetration-challenge
trending-2026
Known Synonyms
Kollaren
Glycyl-histidyl-lysine
Gly-his-lys
NSC 379527
UNII-39TG2H631E
Growth-modulating peptide (human)
Gly-L-His-L-Lys
glycylhistidyllysine
liver cell growth factor
GHK Tripeptide
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1814493
Frequently Asked Questions
Is Copper Tripeptide-1 allowed in the EU?
Copper Tripeptide-1 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Copper Tripeptide-1 do in cosmetics?
Copper Tripeptide-1 functions as: Bioactive copper peptide; stimulates collagen types I, III, and IV and elastin synthesis; modulates matrix metalloproteinases (MMP balance); reduces inflammatory cytokines and oxidative stress markers; attracts immune cells to wound sites; restores fibroblast replicative vitality; emerging hair-growth stimulant. It is classified as a Active Ingredient in our database. CAS number: 49557-75-7.
Is Copper Tripeptide-1 used outside cosmetics?
Copper Tripeptide-1 also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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Chemical family
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COPAIFERA OFFICINALIS RESIN
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Browse nearby
Film Forming, Fragrance
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