Copper Tripeptide-1

INCI: COPPER TRIPEPTIDE-1

CAS Number
49557-75-7
Function
Bioactive copper peptide; stimulates collagen types I, III, and IV and elastin synthesis; modulates matrix metalloproteinases (MMP balance); reduces inflammatory cytokines and oxidative stress markers; attracts immune cells to wound sites; restores fibroblast replicative vitality; emerging hair-growth stimulant
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No FDA restriction on copper tripeptide-1 as a cosmetic ingredient; used in OTC anti-aging serums. Nano copper regulation not applicable to peptide form.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

One of the most-marketed bioactive peptides for 2025โ€“2026 with strong mechanistic rationale for collagen and elastin stimulation, MMP modulation, and anti-inflammatory effects; clinical trials confirm improved skin density, thickness, hydration, and reduced lines/wrinkles over 12 weeks with emerging hair growth applications. Key formulation challenges are stability and dermal penetration; EU nano copper ban does not affect this soluble peptide form. Recommended for premium anti-aging and hair serums.

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Concern Level: Low

Regulatory Flags

bioactive-peptide collagen-booster anti-aging mmp-modulator anti-inflammatory hair-growth copper-complex stability-sensitive penetration-challenge trending-2026

Frequently Asked Questions

Is Copper Tripeptide-1 safe in cosmetics?

One of the most-marketed bioactive peptides for 2025โ€“2026 with strong mechanistic rationale for collagen and elastin stimulation, MMP modulation, and anti-inflammatory effects; clinical trials confirm improved skin density, thickness, hydration, and reduced lines/wrinkles over 12 weeks with emerging hair growth applications. Key formulation challenges are stability and dermal penetration; EU nano copper ban does not affect this soluble peptide form. Recommended for premium anti-aging and hair serums. The EU classifies Copper Tripeptide-1 as "permitted". Safety rating: GOOD.

Is Copper Tripeptide-1 allowed in the EU?

Copper Tripeptide-1 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Copper Tripeptide-1 do in cosmetics?

Copper Tripeptide-1 functions as: Bioactive copper peptide; stimulates collagen types I, III, and IV and elastin synthesis; modulates matrix metalloproteinases (MMP balance); reduces inflammatory cytokines and oxidative stress markers; attracts immune cells to wound sites; restores fibroblast replicative vitality; emerging hair-growth stimulant. It is classified as a Active Ingredient in our database. CAS number: 49557-75-7.

What is the Margin of Safety for Copper Tripeptide-1?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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