Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for FD&C Yellow No. 5 (CI 19140). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 750 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 750 mg/kg bw/day | oral | rat | Multigeneration Reproductive | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rabbit | Developmental | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 2500 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 2500 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 1500 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| NOAEL | 2641 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 984 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 7500 mg/kg bw/day | oral | mouse | Chronic | COSMOS_DB |
Expert Verdict
Good safety profile with established concentration limits; generally considered safe for cosmetic use.
Regulatory Flags
Frequently Asked Questions
Is FD&C Yellow No. 5 (CI 19140) safe in cosmetics?
Good safety profile with established concentration limits; generally considered safe for cosmetic use. The EU classifies FD&C Yellow No. 5 (CI 19140) as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is FD&C Yellow No. 5 (CI 19140) allowed in the EU?
FD&C Yellow No. 5 (CI 19140) EU regulatory status: permitted. Maximum allowed concentration: 0.11%. This is based on EU Regulation 1223/2009 and its amendments.
What does FD&C Yellow No. 5 (CI 19140) do in cosmetics?
FD&C Yellow No. 5 (CI 19140) functions as: Colorant. It is classified as a Cosmetic Ingredient in our database. CAS number: 1934-21-0.
What is the Margin of Safety for FD&C Yellow No. 5 (CI 19140)?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for FD&C Yellow No. 5 (CI 19140)?
The NOAEL (No Observed Adverse Effect Level) for FD&C Yellow No. 5 (CI 19140) is 750 mg/kg bw/day based on a Chronic study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check FD&C Yellow No. 5 (CI 19140) compliance across multiple jurisdictions:
Related Ingredients
Is FD&C Yellow No. 5 (CI 19140) in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for FD&C Yellow No. 5 (CI 19140) in your formulation.