Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
7 study endpoints found for Germanium Dioxide. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 72 2104 | 1992 | rat | inhalation | REACH |
| LOAEL | 37.5 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 100 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 100 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 100 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 10 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 100 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Serious safety concerns: H318 hazard (serious eye damage) precludes use near eyes; chronic germanium exposure linked to renal failure, peripheral neuropathy, and myopathy; limited carcinogenicity data.
Frequently Asked Questions
Is Germanium Dioxide safe in cosmetics?
Serious safety concerns: H318 hazard (serious eye damage) precludes use near eyes; chronic germanium exposure linked to renal failure, peripheral neuropathy, and myopathy; limited carcinogenicity data. The EU classifies Germanium Dioxide as "prohibited". Safety rating: POOR. 7 toxicological study endpoint(s) are available in our database.
Is Germanium Dioxide allowed in the EU?
Germanium Dioxide EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Germanium Dioxide do in cosmetics?
Germanium Dioxide functions as: Skin conditioning; also used in electronics and optics. It is classified as a cosmetic ingredient in our database. CAS number: 1310-53-8.
What is the Margin of Safety for Germanium Dioxide?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Germanium Dioxide?
The NOAEL (No Observed Adverse Effect Level) for Germanium Dioxide is 72 2104 based on a inhalation study via 1992 route in rat. A total of 7 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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