Is Glabridin safe in cosmetics?
Glabridin has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Active Ingredient
Glabridin
INCI: GLABRIDIN
Glabridin (CAS 59870-68-7) is a cosmetic active ingredient functioning as Tyrosinase inhibitor; cyclooxygenase inhibitor (reduces PGE2-driven. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 59870-68-7 →
Auto-generated CPSR Part A draft with source citations
Function
Tyrosinase inhibitor; cyclooxygenase inhibitor (reduces PGE2-driven melanogenesis); anti-inflammatory; oil-soluble isoflavane from licorice root (Glycyrrhiza glabra); dual depigmenting and anti-inflammatory mechanism
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No FDA restriction. Used in cosmetic brightening formulations at 0.2–1%. Not classified as a drug. Licorice root extract GRAS as food flavouring provides indirect safety support.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Glabridin.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
2 property records from structured ingredient metadata.
skin_brightening
{"cas_number": "59870-68-7", "mechanism_of_action": "Tyrosinase inhibition; ROS scavenging", "melanogenesis_pathway_target": "Tyrosinase; oxidative stress", "tyrosinase_inhibition_ic50_um": "~30-50", "tyrosinase_inhibition_vs_kojic_acid": "~2-3x more potent", "melanosome_transfer_inhibitor": "Partial", "melanin_oxidation_reducer": "Yes", "endothelin_pathway_blocker": "No", "alpha_msh_antagonist": …
skin_suitability
{"oily_skin": "acceptable", "dry_skin": "acceptable", "sensitive_skin": "recommended", "combination_skin": "acceptable", "normal_skin": "acceptable", "acne_prone": "acceptable", "rosacea": "recommended", "eczema": "recommended", "hyperpigmentation": "recommended", "aging_mature": "acceptable", "dehydrated": "acceptable", "skin_benefit_primary": "brightening", "skin_benefit_secondary": "anti-inflam…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Bleaching agent
Expert Verdict
Expert safety assessment and concern-level summary for Glabridin.
Regulatory Flags
tyrosinase-inhibitor
brightening
cyclooxygenase-inhibitor
pge2-reduction
anti-inflammatory
licorice-natural
oil-soluble
melasma
uv-pigmentation
dual-mechanism
category-b-japan
eu-allowed
us-allowed
oil-phase-brightening
endocrine_disruptor
Chemical Function
Bleaching agent
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
GLABRIDIN
ChEMBL ID
CHEMBL480477
Frequently Asked Questions
Is Glabridin allowed in the EU?
Glabridin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Glabridin do in cosmetics?
Glabridin functions as: Tyrosinase inhibitor; cyclooxygenase inhibitor (reduces PGE2-driven melanogenesis); anti-inflammatory; oil-soluble isoflavane from licorice root (Glycyrrhiza glabra); dual depigmenting and anti-inflammatory mechanism. It is classified as a Active Ingredient in our database. CAS number: 59870-68-7.
Is Glabridin used outside cosmetics?
Glabridin also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Glabridin compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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