Regulatory Status
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Safety Data
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Expert Verdict
Natural oil-soluble tyrosinase inhibitor from licorice root with dual brightening mechanism: direct tyrosinase inhibition plus cyclooxygenase inhibition reducing PGE2-driven melanocyte stimulation. Double-blind clinical study confirmed efficacy at 0.2% for melasma with Japan Category B classification. Not EU or US restricted. Oil-solubility makes it ideal for rich creams, face oils, and oil-dominant emulsions where it complements aqueous-phase actives.
Regulatory Flags
Frequently Asked Questions
Is Glabridin safe in cosmetics?
Natural oil-soluble tyrosinase inhibitor from licorice root with dual brightening mechanism: direct tyrosinase inhibition plus cyclooxygenase inhibition reducing PGE2-driven melanocyte stimulation. Double-blind clinical study confirmed efficacy at 0.2% for melasma with Japan Category B classification. Not EU or US restricted. Oil-solubility makes it ideal for rich creams, face oils, and oil-dominant emulsions where it complements aqueous-phase actives. The EU classifies Glabridin as "permitted". Safety rating: GOOD.
Is Glabridin allowed in the EU?
Glabridin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Glabridin do in cosmetics?
Glabridin functions as: Tyrosinase inhibitor; cyclooxygenase inhibitor (reduces PGE2-driven melanogenesis); anti-inflammatory; oil-soluble isoflavane from licorice root (Glycyrrhiza glabra); dual depigmenting and anti-inflammatory mechanism. It is classified as a Active Ingredient in our database. CAS number: 59870-68-7.
What is the Margin of Safety for Glabridin?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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