Hexapeptide-40 SH-Oligopeptide-1

INCI: HEXAPEPTIDE-40 SH-OLIGOPEPTIDE-1

CAS Number
Not publicly available
Function
Skin conditioning (biotech-derived fusion peptide; SH-Oligopeptide-1 = synthetic human EGF analog)
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” not listed as prohibited/restricted in 21 CFR; no CIR monograph

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

SH-Oligopeptide-1 is a synthetic human EGF analog that faces heightened regulatory scrutiny due to theoretical proliferative concerns; growth factor peptides may be flagged by CPSR assessors. Complete supplier toxicology package required; verify no product claims that could trigger medicinal product reclassification.

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Concern Level: High

Frequently Asked Questions

Is Hexapeptide-40 SH-Oligopeptide-1 safe in cosmetics?

SH-Oligopeptide-1 is a synthetic human EGF analog that faces heightened regulatory scrutiny due to theoretical proliferative concerns; growth factor peptides may be flagged by CPSR assessors. Complete supplier toxicology package required; verify no product claims that could trigger medicinal product reclassification. The EU classifies Hexapeptide-40 SH-Oligopeptide-1 as "permitted". Safety rating: POOR.

Is Hexapeptide-40 SH-Oligopeptide-1 allowed in the EU?

Hexapeptide-40 SH-Oligopeptide-1 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hexapeptide-40 SH-Oligopeptide-1 do in cosmetics?

Hexapeptide-40 SH-Oligopeptide-1 functions as: Skin conditioning (biotech-derived fusion peptide; SH-Oligopeptide-1 = synthetic human EGF analog). It is classified as a cosmetic ingredient in our database. CAS number: Not publicly available.

What is the Margin of Safety for Hexapeptide-40 SH-Oligopeptide-1?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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