Hexyldecyl Ethylhexanoate

INCI: HEXYLDECYL ETHYLHEXANOATE

CAS Number
Not individually established
Function
Skin conditioning — emollient (alkyl ester)
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status permitted
US Notes Permitted — however, deleted from CIR alkyl esters review due to fetotoxicity concern with metabolite 2-ethylhexanoic acid

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

CIR Expert Panel deleted all ethylhexanoate esters from the 2012 alkyl esters safety assessment due to concern that 2-ethylhexanoic acid, a metabolite of ethylhexanoate esters, is a known fetotoxicant. No standalone CIR assessment has been published. Use requires independent toxicological justification with reproductive toxicity data.

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Concern Level: High

Frequently Asked Questions

Is Hexyldecyl Ethylhexanoate safe in cosmetics?

CIR Expert Panel deleted all ethylhexanoate esters from the 2012 alkyl esters safety assessment due to concern that 2-ethylhexanoic acid, a metabolite of ethylhexanoate esters, is a known fetotoxicant. No standalone CIR assessment has been published. Use requires independent toxicological justification with reproductive toxicity data. The EU classifies Hexyldecyl Ethylhexanoate as "prohibited". Safety rating: POOR.

Is Hexyldecyl Ethylhexanoate allowed in the EU?

Hexyldecyl Ethylhexanoate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Hexyldecyl Ethylhexanoate do in cosmetics?

Hexyldecyl Ethylhexanoate functions as: Skin conditioning — emollient (alkyl ester). It is classified as a cosmetic ingredient in our database. CAS number: Not individually established.

What is the Margin of Safety for Hexyldecyl Ethylhexanoate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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