Excellent Cosmetic Ingredient GHS Classified

Isobutane

INCI: ISOBUTANE

CAS Number
75-28-5
Function
Propellant for aerosol cosmetics
Safety Rating
EXCELLENT

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted — CIR reviewed and concluded safe for cosmetic use as propellant; 21 CFR does not restrict

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
Rapid evaporation of the liquid may cause frostbite. The substance may cause effects on the cardiovascular system. This may result in impaired functions and respiratory failure. Exposure at high levels could cause death.
Routes of Exposure
The substance can be absorbed into the body by inhalation.

Expert Verdict

Flammable gas with inhalation abuse risk; ensure adequate ventilation during use. No dermal toxicity concern in cosmetic applications.

⚠️
Concern Level: Low

Regulatory Flags

eu_banned_cosmetics eu_children_restricted fda_food_additive eu_cosing_listed

Frequently Asked Questions

Is Isobutane safe in cosmetics?

Flammable gas with inhalation abuse risk; ensure adequate ventilation during use. No dermal toxicity concern in cosmetic applications. The EU classifies Isobutane as "permitted". Safety rating: EXCELLENT.

Is Isobutane allowed in the EU?

Isobutane EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Isobutane do in cosmetics?

Isobutane functions as: Propellant for aerosol cosmetics. It is classified as a cosmetic ingredient in our database. CAS number: 75-28-5.

What is the Margin of Safety for Isobutane?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Isobutane compliance across multiple jurisdictions:

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Ingredient Decoder
Paste a full ingredient list for instant analysis
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82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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