Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for L-Tryptophan. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1250 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 3750 mg/kg bw/day | oral | mouse | Carcinogenicity | COSMOS_DB |
| NOAEL | 5000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 7500 mg/kg bw/day | oral | mouse | Short Term Toxicity | COSMOS_DB |
| NOAEL | 400 mg/kg bw/day | oral | swine | Short Term Toxicity | COSMOS_DB |
| NOAEL | 1600 mg/kg bw/day | oral | swine | Short Term Toxicity | COSMOS_DB |
| NOAEL | 2000 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 1153 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
Expert Verdict
Essential amino acid with antistatic, hair-conditioning, and masking functions; safe for topical use with negligible systemic exposure at typical cosmetic concentrations
Regulatory Flags
Frequently Asked Questions
Is L-Tryptophan safe in cosmetics?
Essential amino acid with antistatic, hair-conditioning, and masking functions; safe for topical use with negligible systemic exposure at typical cosmetic concentrations The EU classifies L-Tryptophan as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is L-Tryptophan allowed in the EU?
L-Tryptophan EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does L-Tryptophan do in cosmetics?
L-Tryptophan functions as: Antistatic, Hair conditioning, Masking. It is classified as a cosmetic ingredient in our database. CAS number: 73-22-3.
What is the Margin of Safety for L-Tryptophan?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for L-Tryptophan?
The NOAEL (No Observed Adverse Effect Level) for L-Tryptophan is 1250 mg/kg bw/day based on a Carcinogenicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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