Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for L-Valine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 3721 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 628 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 3225 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
L-Valine is a branched-chain amino acid whose hydrophobic side chain enables access to lipid-phase ROS, inhibiting lipid peroxidation. Classified as a fat-soluble ROS-accessible antioxidant in skin. GRAS and CIR-class safe with no restrictions.
Regulatory Flags
Frequently Asked Questions
Is L-Valine safe in cosmetics?
L-Valine is a branched-chain amino acid whose hydrophobic side chain enables access to lipid-phase ROS, inhibiting lipid peroxidation. Classified as a fat-soluble ROS-accessible antioxidant in skin. GRAS and CIR-class safe with no restrictions. The EU classifies L-Valine as "permitted". Safety rating: EXCELLENT. 3 toxicological study endpoint(s) are available in our database.
Is L-Valine allowed in the EU?
L-Valine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does L-Valine do in cosmetics?
L-Valine functions as: Essential branched-chain amino acid that inhibits lipid peroxidation and enhances the accessibility of fat-soluble reactive oxygen species (ROS) for scavenging. The hydrophobic branched-chain side chain of valine partitions into lipid-rich environments (sebum, membrane bilayers), enabling antioxidant protection in the lipid phase of the skin. Component of the free amino acid antioxidant pool.. It is classified as a Antioxidant in our database. CAS number: 72-18-4.
What is the Margin of Safety for L-Valine?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for L-Valine?
The NOAEL (No Observed Adverse Effect Level) for L-Valine is 3721 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 3 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check L-Valine compliance across multiple jurisdictions:
Related Ingredients
Is L-Valine in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for L-Valine in your formulation.