Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Lab-Grown Squalane. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | ca.10000 mg/kg bw/day | oral | rat | oral | REACH |
Dermal Penetration Profile
Skin absorption and penetration characteristics of Lab-Grown Squalane, relevant to systemic exposure and MoS calculations.
Source: Cosmetic Science
Expert Verdict
Lab-grown squalane is a fermentation-derived alternative chemically identical to conventional squalane with full supply chain traceability and no regulatory or safety differentiation.
Regulatory Flags
Frequently Asked Questions
Is Lab-Grown Squalane safe in cosmetics?
Lab-grown squalane is a fermentation-derived alternative chemically identical to conventional squalane with full supply chain traceability and no regulatory or safety differentiation. The EU classifies Lab-Grown Squalane as "permitted". Safety rating: EXCELLENT. 1 toxicological study endpoint(s) are available in our database.
Is Lab-Grown Squalane allowed in the EU?
Lab-Grown Squalane EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Lab-Grown Squalane do in cosmetics?
Lab-Grown Squalane functions as: Biotechnology-derived squalane produced via precision fermentation using engineered yeast from sugarcane feedstock. Chemically identical to olive or shark-derived squalane. Emollient, barrier support, skin-identical lipid.. It is classified as a Emollient in our database. CAS number: 111-01-3.
What is the Margin of Safety for Lab-Grown Squalane?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Lab-Grown Squalane?
The NOAEL (No Observed Adverse Effect Level) for Lab-Grown Squalane is ca.10000 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.
Compliance Tools
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Related Ingredients
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