Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Lactoflavin. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 400 mg/kg bw/day | oral | mouse | Short Term Toxicity | COSMOS_DB |
| NOAEL | 400 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 400 mg/kg bw/day | oral | dog | Short Term Toxicity | COSMOS_DB |
| NOAEL | 400 mg/kg bw/day | oral | cat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 400 mg/kg bw/day | oral | rabbit | Short Term Toxicity | COSMOS_DB |
| NOAEL | 25 mg/kg bw/day | oral | dog | Subchronic | COSMOS_DB |
| NOAEL | 50 mg/kg bw/day | oral | rat | Multigeneration Reproductive | COSMOS_DB |
| NOAEL | 10 mg/kg bw/day | oral | rat | Reproductive | COSMOS_DB |
| NOAEL | 4 mg/kg bw/day | oral | rat | Reproductive | COSMOS_DB |
| dose_tested | 400 mg/kg bw/day | oral | mouse | Short Term Toxicity | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Photosensitive compound that degrades under UV/visible light; formulation must address light stability and potential yellow coloration, but no toxicological concerns at cosmetic use levels.
Regulatory Flags
Frequently Asked Questions
Is Lactoflavin safe in cosmetics?
Photosensitive compound that degrades under UV/visible light; formulation must address light stability and potential yellow coloration, but no toxicological concerns at cosmetic use levels. The EU classifies Lactoflavin as "permitted". Safety rating: EXCELLENT. 10 toxicological study endpoint(s) are available in our database.
Is Lactoflavin allowed in the EU?
Lactoflavin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Lactoflavin do in cosmetics?
Lactoflavin functions as: Skin conditioning agent; colorant (CI 75170). It is classified as a cosmetic ingredient in our database. CAS number: 83-88-5.
What is the Margin of Safety for Lactoflavin?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Lactoflavin?
The NOAEL (No Observed Adverse Effect Level) for Lactoflavin is 400 mg/kg bw/day based on a Short Term Toxicity study via oral route in mouse. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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