Is Luteolin safe in cosmetics?
Luteolin has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Antioxidant
Luteolin
Also known as: C.I. Natural Yellow 2, BRN 0292084, EINECS 207-741-0, UNII-KUX1ZNC9J2, Salifazide
INCI: LUTEOLIN
Luteolin (CAS 491-70-3) is a cosmetic antioxidant functioning as Skin Conditioning, Antioxidant, Anti-Inflammatory. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 491-70-3 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning, Antioxidant, Anti-Inflammatory
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one
InChIKey
IQPNAANSBPBGFQ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No dedicated CIR Final Safety Assessment. No specific FDA restrictions.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Luteolin.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
4 property records from structured ingredient metadata.
acne
{"cas_number": "491-70-3", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-10", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction_…
anti_pollution
{"cas_number": "491-70-3", "ingredient_class": "AhR_antagonist", "primary_mechanism": "free_radical_scavenging", "pollution_types_targeted": "PM2_5/PAH", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "…
antioxidant
{"cas_number": "491-70-3", "antioxidant_class": "flavonoid", "chemical_subclass": "flavone", "molecular_weight_daltons": "286.24", "orac_value_umol_te_per_g": "14800", "dpph_radical_scavenging_ic50_ug_per_ml": "10-19", "abts_trolox_equivalent": "not available", "singlet_oxygen_quenching": "not available", "superoxide_dismutase_mimetic": "not available", "hydroxyl_radical_scavenging": "not availabl…
depigmentation
{"cas_number": "491-70-3", "ingredient_class": "tyrosinase_inhibitor", "primary_mechanism_of_action": "Flavone with potent tyrosinase inhibition", "secondary_mechanisms": "Variable", "molecular_target": "tyrosinase", "tyrosinase_inhibition_IC50_uM": "varies", "tyrosinase_inhibition_type": "competitive", "melanin_reduction_pct_in_vitro": "25-45", "melanin_reduction_pct_clinical": "15-30", "onset_of…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Luteolin.
Regulatory Flags
endocrine_disruptor
Known Synonyms
C.I. Natural Yellow 2
BRN 0292084
EINECS 207-741-0
UNII-KUX1ZNC9J2
Salifazide
Chemical Function
Softener and conditioner
Regulatory Lists
Canada; pharmaceutical
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
LUTEOLIN
ChEMBL ID
CHEMBL151
Max Phase
2
Adverse Event Associations
7
Frequently Asked Questions
Is Luteolin allowed in the EU?
Luteolin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Luteolin do in cosmetics?
Luteolin functions as: Skin Conditioning, Antioxidant, Anti-Inflammatory. It is classified as a Antioxidant in our database. CAS number: 491-70-3.
Is Luteolin used outside cosmetics?
Luteolin also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Luteolin compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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