Methylcobalamin

CAS Number
13422-55-4
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

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Concern Level: Low

Regulatory Flags

active-b12-form methyl-donor no-conversion-required more-bioavailable-than-cyanocobalamin microbiome-acne-risk p-acnes-porphyrin-promotion light-sensitive opaque-packaging-required avoid-acne-formulations

Frequently Asked Questions

Is Methylcobalamin safe in cosmetics?

Methylcobalamin has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.

Is Methylcobalamin allowed in the EU?

Methylcobalamin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What is the Margin of Safety for Methylcobalamin?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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