Is Methylcobalamin safe in cosmetics?
Methylcobalamin has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
MODERATE
Active Ingredient
Methylcobalamin
Also known as: Cobalt-methylcobalamin, EINECS 236-535-3, Vancomin, Cobamet, Cobametin (+3 more)
Methylcobalamin (CAS 13422-55-4) is classified as a active ingredient. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical and food safety data.
View industrial chemical safety profile for CAS 13422-55-4 →
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
carbanide;cobalt(3+);[(2R,3S,4R,5S)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] 1-[3-[(1R,2R,3R,5Z,7S,10Z,12S,13S,15Z,17S,18S,19R)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7,12,17-tetrahydro-1H-corrin-24-id-3-yl]propanoylamino]propan-2-yl phosphate
InChIKey
ZFLASALABLFSNM-WYVZQNDMSA-L
Regulatory Status
EU EU Status
permitted
US US Status
permitted
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Methylcobalamin.
Calculate MoS for your specific formulation with the MoS Calculator.
Editorial summary
Preliminary editorial summary for Methylcobalamin — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
active-b12-form
methyl-donor
no-conversion-required
more-bioavailable-than-cyanocobalamin
microbiome-acne-risk
p-acnes-porphyrin-promotion
light-sensitive
opaque-packaging-required
avoid-acne-formulations
Known Synonyms
Cobalt-methylcobalamin
EINECS 236-535-3
Vancomin
Cobamet
Cobametin
Mecobalaminum
Cobaday
UNII-BR1SN1JS2W
Regulatory Lists
pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
Europe; supplements
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
mecobalamin
ChEMBL ID
CHEMBL2359370
Adverse Event Associations
2508
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Vitamin B12 - Methylcobalamin
Food Category
vitamins_minerals
Frequently Asked Questions
Is Methylcobalamin allowed in the EU?
Methylcobalamin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
Is Methylcobalamin used outside cosmetics?
Methylcobalamin also appears in pharmaceutical and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Methylcobalamin compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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