Good Active Ingredient NOAEL Data

Morus Alba Root Extract

INCI: MORUS ALBA ROOT EXTRACT

CAS Number
544-63-8
Function
Skin brightening, antioxidant, skin conditioning
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes No FDA pre-market approval required for cosmetic use. No CIR assessment for mulberroside F specifically. No GRAS listing relevant to topical use. MoCRA safety substantiation required. Not subject to hydroquinone OTC drug concerns (unlike arbutin).

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Morus Alba Root Extract. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 10000 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 20000 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB

Expert Verdict

Morus alba root extract is an arbutin alternative for skin brightening, permitted in EU cosmetics without Annex restrictions. Key actives mulberroside F and oxyresveratrol inhibit tyrosinase; unlike arbutin, mulberroside F does not release hydroquinone. In vitro efficacy is robust; clinical data are limited. No heavy metal concerns for commercial extracts.

⚠️
Concern Level: Low

Regulatory Flags

eu-unrestricted no-sccs-opinion skin-brightening tyrosinase-inhibitor mulberroside-f oxyresveratrol arbutin-alternative no-hydroquinone-release anti-hyperpigmentation k-beauty in-vitro-evidence eu_children_restricted epa_safer_alternative ifra_fragrance fda_food_additive

Frequently Asked Questions

Is Morus Alba Root Extract safe in cosmetics?

Morus alba root extract is an arbutin alternative for skin brightening, permitted in EU cosmetics without Annex restrictions. Key actives mulberroside F and oxyresveratrol inhibit tyrosinase; unlike arbutin, mulberroside F does not release hydroquinone. In vitro efficacy is robust; clinical data are limited. No heavy metal concerns for commercial extracts. The EU classifies Morus Alba Root Extract as "permitted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.

Is Morus Alba Root Extract allowed in the EU?

Morus Alba Root Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Morus Alba Root Extract do in cosmetics?

Morus Alba Root Extract functions as: Skin brightening, antioxidant, skin conditioning. It is classified as a Active Ingredient in our database. CAS number: 544-63-8.

What is the Margin of Safety for Morus Alba Root Extract?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Morus Alba Root Extract?

The NOAEL (No Observed Adverse Effect Level) for Morus Alba Root Extract is 10000 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check Morus Alba Root Extract compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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