Is Nano Titanium Dioxide safe in cosmetics?
Nano Titanium Dioxide has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted.
Nano Titanium Dioxide
INCI: TITANIUM DIOXIDE
Nano Titanium Dioxide (CAS None) is a cosmetic uv filter / sunscreen functioning as UV Filter. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS None →
Auto-generated CPSR Part A draft with source citations
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
SCCS issued safety assessment opinion on May 23, 2024 regarding titanium dioxide safety.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Nano Titanium Dioxide.
Calculate MoS for your specific formulation with the MoS Calculator.
SCCS NOAEL Values
NOAEL/LOAEL values cited in official SCCS opinions for Nano Titanium Dioxide.
| NOAEL | LOAEL | Route | Species | Study | DA% (SCCS) | Opinion |
|---|---|---|---|---|---|---|
| - | - | Inhalation | Rat | Subchronic (90-day) (90 days (inhalation, 6h/day)) | N/A | SCCS/1617/20 (2020) |
Dermal Penetration Profile
Skin absorption and penetration characteristics of Nano Titanium Dioxide, relevant to systemic exposure and MoS calculations.
Absorption %
0.01-0.05%
Penetration Level
surface
Penetration Depth
surface only
Molecular Weight
79.9 Da
Log P
n/a
Systemic Absorption
no
Topical Bioavailability
0.01%
Safety Margin Factor
none
Source: SCCS/1516/13
Typical Use Concentrations
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Sunscreen | 2–25 | 25 | CIR/VCRP |
| Foundation | 3–20 | 25 | CIR/VCRP |
| Face Powder | 5–25 | 60 | CIR/VCRP |
Additional Ingredient Properties
10 property records from structured ingredient metadata.
acne
{"cas_number": "13463-67-7", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "1", "acne_type_efficacy": "inflammatory/non_inflammatory", "sebum_reduction_pct_clinical": "5-15", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_co…
anti_pollution
{"cas_number": "13463-67-7", "ingredient_class": "blue_light_filter", "primary_mechanism": "film_forming_barrier", "pollution_types_targeted": "blue_light_HEV/UV_A/UV_B", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_mod…
baby_pediatric
{"cas_number": "13463-67-7", "ingredient_class": "sunscreen_baby", "pediatric_safety_rating": "excellent", "minimum_age_months": "6", "neonatal_safe": "yes", "premature_infant_safe": "yes", "skin_barrier_maturity_consideration": "Mineral, UVB-focus, photostable, FDA GRASE", "transepidermal_absorption_risk_pediatric": "very_low", "dose_per_kg_body_weight_concern": "No penetration - surface", "skin_…
colorant_formulator
{"ci_number": "77891", "ci_name": "Pigment White 6 (Anatase)", "color_category": "white", "color_hex_code": "#F8F8F8", "natural_or_synthetic": "synthetic", "organic_or_inorganic": "inorganic", "lake_or_dye": "pigment", "fda_approved_use": "eye/general", "eu_approved_cosmetic": "yes", "japan_approved": "yes", "china_approved": "yes", "ultramarines_type": "anatase", "coverage_opacity": "opaque", "ti…
comedogenicity_detail
{"comedogenicity_rating": "0", "irritancy_rating": "0", "skin_type_suitability": "all,oily,dry,sensitive,combination,normal,acne-prone,rosacea", "acne_safe": "yes", "source": "Physical blocker"}
concentration
{"min_concentration_pct": "2.0", "max_concentration_pct": "15.0", "typical_concentration_pct": "8.0", "product_type": "Tinted Moisturizer SPF", "function_at_concentration": "Physical UV filter", "source": "FDA OTC Monograph"}
dermal_absorption
{"molecular_weight_da": "79.9", "skin_penetration_level": "surface", "penetration_depth": "surface only", "absorption_pct": "0.01-0.05", "systemic_absorption": "no", "penetration_enhancer": "no", "occlusion_effect": "yes", "vehicle_dependent": "no", "skin_barrier_effect": "neutral", "bioavailability_topical_pct": "0.01", "source": "SCCS/1516/13"}
emulsifier
{"cas_number": "13463-67-7", "ingredient_class": "Pickering_emulsifier", "chemical_type": "mineral", "emulsion_type_primary": "O/W", "droplet_size_typical_um": "0.1-1", "lamellar_phase": "no", "hexagonal_phase": "no", "cubic_phase": "no", "gel_network_formation": "no", "viscoelastic_properties": "no", "rheology_modification": "yes", "viscosity_building": "yes", "pseudoplastic_behavior": "no", "thi…
Expert Verdict
Expert safety assessment and concern-level summary for Nano Titanium Dioxide.
Regulatory Flags
EU Restricted
SCCS Review
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Nano Titanium Dioxide by CAS number or substance name.
Studies
3
Lowest NOAEL
1250 mg/kg bw/day
Highest NOAEL
7500 mg/kg bw/day
COSMOS_DB
Frequently Asked Questions
Is Nano Titanium Dioxide allowed in the EU?
Nano Titanium Dioxide EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Nano Titanium Dioxide do in cosmetics?
Nano Titanium Dioxide functions as: UV Filter. It is classified as a UV Filter / Sunscreen in our database. CAS number: None.
Compliance Tools
Check Nano Titanium Dioxide compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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