Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Saccharide Isomerate (CAS 100843-69-4) is a skin-conditioning humectant permitted in EU cosmetics without restriction under Regulation (EC) No 1223/2009 and not listed in any Annex. The CIR Expert Panel concluded in its 2021 Final Report that the ingredient is safe as used in cosmetics at concentrations up to 2.8% leave-on and 0.7% rinse-off. Dermal absorption is negligible due to high molecular weight variants and stratum corneum keratin binding; sensitization and irritation data are consistently negative across both animal and human studies.
Regulatory Flags
Frequently Asked Questions
Is Saccharide Isomerate safe in cosmetics?
Saccharide Isomerate (CAS 100843-69-4) is a skin-conditioning humectant permitted in EU cosmetics without restriction under Regulation (EC) No 1223/2009 and not listed in any Annex. The CIR Expert Panel concluded in its 2021 Final Report that the ingredient is safe as used in cosmetics at concentrations up to 2.8% leave-on and 0.7% rinse-off. Dermal absorption is negligible due to high molecular weight variants and stratum corneum keratin binding; sensitization and irritation data are consistently negative across both animal and human studies. The EU classifies Saccharide Isomerate as "permitted". Safety rating: EXCELLENT.
Is Saccharide Isomerate allowed in the EU?
Saccharide Isomerate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Saccharide Isomerate do in cosmetics?
Saccharide Isomerate functions as: UV Filter. It is classified as a UV Filter / Sunscreen in our database. CAS number: 100843-69-4.
What is the Margin of Safety for Saccharide Isomerate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
Check Saccharide Isomerate compliance across multiple jurisdictions:
Related Ingredients
Is Saccharide Isomerate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Saccharide Isomerate in your formulation.