Moderate Cosmetic Ingredient

Oligopeptide-34

INCI: OLIGOPEPTIDE-34

CAS Number
2227218-62-2
Function
Skin conditioning, skin brightening (multi-target melanogenesis inhibitor: tyrosinase, TRP-1, TRP-2, MITF downregulation)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes No FDA ingredient-specific restrictions. Not reviewed by CIR. Falls under general cosmetic framework and MoCRA registration requirements. No GRASE classification. Supplier toxicological dossier should be requested from Caregen or Spec-Chem to support safety substantiation.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Oligopeptide-34 (CAS 2227218-62-2) is permitted in the EU as a skin conditioning agent with no concentration restrictions and is not restricted under Regulation (EC) No 1223/2009; in the US, it is permitted as a cosmetic ingredient with no FDA-specific restrictions but requires safety substantiation through dermal penetration and sensitization studies.

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Concern Level: Moderate

Regulatory Flags

no-sccs-opinion no-cir-review no-mos-calculated no-dermal-absorption-data no-sensitization-data data-gap-high supplier-dossier-required

Frequently Asked Questions

Is Oligopeptide-34 safe in cosmetics?

Oligopeptide-34 (CAS 2227218-62-2) is permitted in the EU as a skin conditioning agent with no concentration restrictions and is not restricted under Regulation (EC) No 1223/2009; in the US, it is permitted as a cosmetic ingredient with no FDA-specific restrictions but requires safety substantiation through dermal penetration and sensitization studies. The EU classifies Oligopeptide-34 as "permitted". Safety rating: MODERATE.

Is Oligopeptide-34 allowed in the EU?

Oligopeptide-34 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Oligopeptide-34 do in cosmetics?

Oligopeptide-34 functions as: Skin conditioning, skin brightening (multi-target melanogenesis inhibitor: tyrosinase, TRP-1, TRP-2, MITF downregulation). It is classified as a cosmetic ingredient in our database. CAS number: 2227218-62-2.

What is the Margin of Safety for Oligopeptide-34?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Oligopeptide-34 compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

Related Ingredients

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Oligopeptide-20
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Tripeptide-32
Moderate
Dipeptide-4
Good
Palmitoyl Oligopeptide
Good
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