Palmitoyl Heptapeptide-14

INCI: PALMITOYL HEPTAPEPTIDE-14

CAS Number
Not assigned
Function
Skin conditioning, anti-aging (collagen/elastin promotion via intracellular delivery)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not reviewed by CIR for this specific INCI. CIR 2014 review covered structurally analogous palmitoyl peptides and found them safe at <10 ppm; findings are not directly transferable to Palmitoyl Heptapeptide-14 due to different chain length, sequence, and copper chelate. No FDA monograph, advisory, or GRASE classification applies.

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Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Palmitoyl Heptapeptide-14 has no public CAS assigned. Listed in CosIng as Copper Palmitoyl Heptapeptide-14; not in EU Annex II/III/IV/V/VI and permitted under EC 1223/2009 subject to Responsible Person safety assessment. Not independently reviewed by CIR; copper ion contribution should be assessed for heavy metal load in EU Article 10 dossier. No published dermal absorption or formal sensitization study data available, though structurally analogous palmitoyl peptides showed acceptable safety profiles.

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Concern Level: Low

Regulatory Flags

data-gap no-cas no-mos no-hript no-absorption-data no-genotoxicity-data cir-not-reviewed copper-complex proprietary-sequence manufacturer-data-required

Frequently Asked Questions

Is Palmitoyl Heptapeptide-14 safe in cosmetics?

Palmitoyl Heptapeptide-14 has no public CAS assigned. Listed in CosIng as Copper Palmitoyl Heptapeptide-14; not in EU Annex II/III/IV/V/VI and permitted under EC 1223/2009 subject to Responsible Person safety assessment. Not independently reviewed by CIR; copper ion contribution should be assessed for heavy metal load in EU Article 10 dossier. No published dermal absorption or formal sensitization study data available, though structurally analogous palmitoyl peptides showed acceptable safety profiles. The EU classifies Palmitoyl Heptapeptide-14 as "permitted". Safety rating: MODERATE.

Is Palmitoyl Heptapeptide-14 allowed in the EU?

Palmitoyl Heptapeptide-14 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Palmitoyl Heptapeptide-14 do in cosmetics?

Palmitoyl Heptapeptide-14 functions as: Skin conditioning, anti-aging (collagen/elastin promotion via intracellular delivery). It is classified as a cosmetic ingredient in our database. CAS number: Not assigned.

What is the Margin of Safety for Palmitoyl Heptapeptide-14?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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