Is Matrixyl (Palmitoyl Pentapeptide-4) safe in cosmetics?
Matrixyl (Palmitoyl Pentapeptide-4) has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
GOOD
Active Ingredient
Matrixyl (Palmitoyl Pentapeptide-4)
INCI: PALMITOYL PENTAPEPTIDE-4
Matrixyl (Palmitoyl Pentapeptide-4) (CAS 214047-00-4) is a cosmetic active ingredient functioning as Peptide anti-aging active. EU Regulation 1223/2009 status: permitted, max 0.0035%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 214047-00-4 →
Function
Peptide anti-aging active
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
permitted
EU Max Conc.
0.0035%
US US Status
permitted
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Matrixyl (Palmitoyl Pentapeptide-4).
Calculate MoS for your specific formulation with the MoS Calculator.
Editorial summary
Preliminary editorial summary for Matrixyl (Palmitoyl Pentapeptide-4) — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Lists
Canada
Personal care
Substances in PCP - Canada (4/2014)
Australian Status
AICIS status: listed_with_terms
Assessment: This chemical has been assessed as a component of dermal cosmetic products at concentrations no more than 0.0005%. This chemical is not to be used in the eye.
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL451881
Frequently Asked Questions
Is Matrixyl (Palmitoyl Pentapeptide-4) allowed in the EU?
Matrixyl (Palmitoyl Pentapeptide-4) EU regulatory status: permitted. Maximum allowed concentration: 0.0035%. This is based on EU Regulation 1223/2009 and its amendments.
What does Matrixyl (Palmitoyl Pentapeptide-4) do in cosmetics?
Matrixyl (Palmitoyl Pentapeptide-4) functions as: Peptide anti-aging active. It is classified as a Active Ingredient in our database. CAS number: 214047-00-4.
Is Matrixyl (Palmitoyl Pentapeptide-4) used outside cosmetics?
Matrixyl (Palmitoyl Pentapeptide-4) also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Matrixyl (Palmitoyl Pentapeptide-4) compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Acetyl Tetrapeptide-5
EXCELLENT
Same category
Anti-edema peptide for periorbital ar...
Activated Charcoal
EXCELLENT
Same category
Adsorbent; skin cleanser; pore-cleans...
Adenosine
EXCELLENT
Same category
Skin-conditioning agent, anti-aging, ...
Allantoin
EXCELLENT
Same category
Skin conditioner, keratolytic, anti-i...
Alpha-Glucan Oligosaccharide
EXCELLENT
Same category
prebiotic, skin-conditioning
Ascophyllum Nodosum Extract
EXCELLENT
Same category
Skin Brightening, Tyrosinase Inhibito...
(AGARICUS BLAZEI FERMENT + GANODERMA LUCIDUM FERMENT + GANODERMA MULTIPILEUM FERMENT) EXTRACT
GOOD
Similar safety
Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA) ROOT/CNIDIUM OFFICINALE RHIZOME EXTRACT
GOOD
Similar safety
Skin Conditioning, Skin Conditioning ...
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT
GOOD
Similar safety
(ANGELICA GIGAS/GLYCYRRHIZA URALENSIS/REHMANNIA GLUTINOSA ROOT)/ANGELICA GIGAS STEM/CARTHAMUS TINCTORIUS FLOWER/(CARTHAMUS TINCTORIUS/PRUNUS PERSICA SEED)PORIA COCOS WATER
GOOD
Similar safety
Humectant, Skin Conditioning, Skin Pr...
(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
GOOD
Similar safety
Anti-seborrheic, Anti-sebum, Antioxid...
(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
GOOD
Similar safety
Antioxidant
Palmitoyl Pentapeptide-4 (formerly Palmitoyl Pentapeptide-3)
GOOD
Chemical family
Skin conditioning agent, Collagen sti...
MCE (S87)
GOOD
Browse nearby
Insufficient data
MDM Hydantoin
MODERATE
Browse nearby
Antimicrobial - helps control the gro...
Is Matrixyl (Palmitoyl Pentapeptide-4) in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Matrixyl (Palmitoyl Pentapeptide-4) in your formulation.