Is Matrixyl (Palmitoyl Pentapeptide-4) safe in cosmetics?
Matrixyl (Palmitoyl Pentapeptide-4) has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Active Ingredient
Matrixyl (Palmitoyl Pentapeptide-4)
INCI: PALMITOYL PENTAPEPTIDE-4
Matrixyl (Palmitoyl Pentapeptide-4) (CAS 214047-00-4) is a cosmetic active ingredient functioning as Peptide anti-aging active. EU Regulation 1223/2009 status: permitted, max 0.0035%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 214047-00-4 →
Auto-generated CPSR Part A draft with source citations
Function
Peptide anti-aging active
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
EU Max Conc.
0.0035%
US US Status
permitted
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Matrixyl (Palmitoyl Pentapeptide-4).
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
8 property records from structured ingredient metadata.
amino_acid
{"cas_number": "214047-00-4", "ingredient_class": "oligopeptide", "source_origin": "synthetic", "molecular_weight_range_Da": "802", "amino_acid_composition_key": "palmitoyl_KTTKS", "charge_at_pH_5_5": "cationic", "water_solubility": "soluble", "oil_solubility": "partially", "film_forming_ability": "poor", "moisture_binding_capacity": "moderate", "NMF_component": "no", "skin_penetration_depth": "de…
anti_pollution
{"cas_number": "214047-00-4", "ingredient_class": "other", "primary_mechanism": "barrier_reinforcement", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_kB_inhibi…
comedogenicity_detail
{"comedogenicity_rating": "0", "irritancy_rating": "0", "skin_type_suitability": "all,dry,combination,normal,mature", "acne_safe": "yes", "source": "Matrixyl - anti-aging"}
concentration
{"min_concentration_pct": "0.001", "max_concentration_pct": "0.3", "typical_concentration_pct": "0.03", "product_type": "Moisturizer", "function_at_concentration": "Anti-aging", "source": "Supplier TDS"}
pediatric_safety
{"safe_for_newborn_0_6m": "caution", "safe_for_infant_6_12m": "caution", "safe_for_toddler_1_3y": "yes", "safe_for_child_3_12y": "yes", "safe_for_teen_12_18y": "yes", "pediatric_max_concentration_pct": "0.5", "adult_max_concentration_pct": "5.0", "pediatric_dermal_absorption_factor": "moderate", "immature_skin_barrier_risk": "low", "oral_ingestion_risk": "low", "eye_irritation_risk": "low", "diape…
peptide
{"cas_number": "214047-00-4", "trade_name": "Matrixyl (original)", "peptide_sequence_amino_acids": "Pal-Lys-Thr-Thr-Lys-Ser", "peptide_length_residues": "5", "molecular_weight_daltons": "802.0", "peptide_class": "signal", "mechanism_of_action": "Stimulates fibroblast proliferation and extracellular matrix protein synthesis", "target_protein_or_receptor": "TGF-beta receptor pathway", "biomimetic_of…
regulatory
{"eu_status": "allowed", "us_status": "allowed"}
skin_suitability
{"oily_skin": "acceptable", "dry_skin": "recommended", "sensitive_skin": "acceptable", "combination_skin": "acceptable", "normal_skin": "recommended", "acne_prone": "acceptable", "rosacea": "acceptable", "eczema": "acceptable", "hyperpigmentation": "acceptable", "aging_mature": "recommended", "dehydrated": "recommended", "skin_benefit_primary": "anti-aging", "skin_benefit_secondary": "firming", "m…
Expert Verdict
Expert safety assessment and concern-level summary for Matrixyl (Palmitoyl Pentapeptide-4).
Regulatory Lists
Canada
Personal care
Substances in PCP - Canada (4/2014)
Australian Status
AICIS status: listed_with_terms
Assessment: This chemical has been assessed as a component of dermal cosmetic products at concentrations no more than 0.0005%. This chemical is not to be used in the eye.
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL451881
Frequently Asked Questions
Is Matrixyl (Palmitoyl Pentapeptide-4) allowed in the EU?
Matrixyl (Palmitoyl Pentapeptide-4) EU regulatory status: permitted. Maximum allowed concentration: 0.0035%. This is based on EU Regulation 1223/2009 and its amendments.
What does Matrixyl (Palmitoyl Pentapeptide-4) do in cosmetics?
Matrixyl (Palmitoyl Pentapeptide-4) functions as: Peptide anti-aging active. It is classified as a Active Ingredient in our database. CAS number: 214047-00-4.
Is Matrixyl (Palmitoyl Pentapeptide-4) used outside cosmetics?
Matrixyl (Palmitoyl Pentapeptide-4) also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Matrixyl (Palmitoyl Pentapeptide-4) compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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