Piper Methysticum Root

INCI: PIPER METHYSTICUM ROOT

CAS Number
84696-40-2
Function
Skin conditioning
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status restricted
US Notes Not FDA-restricted for topical cosmetic use; however, CIR Expert Panel concluded data are insufficient to confirm safety in cosmetics

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Known hepatotoxicant via oral route; CIR data-insufficient verdict; kavalactone content must be characterised; use in leave-on products is high-risk without supporting MoS calculation

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Concern Level: High

Frequently Asked Questions

Is Piper Methysticum Root safe in cosmetics?

Known hepatotoxicant via oral route; CIR data-insufficient verdict; kavalactone content must be characterised; use in leave-on products is high-risk without supporting MoS calculation The EU classifies Piper Methysticum Root as "restricted". Safety rating: POOR.

Is Piper Methysticum Root allowed in the EU?

Piper Methysticum Root EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Piper Methysticum Root do in cosmetics?

Piper Methysticum Root functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 84696-40-2.

What is the Margin of Safety for Piper Methysticum Root?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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