Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Dermal Penetration Profile
Skin absorption and penetration characteristics of Proline, relevant to systemic exposure and MoS calculations.
Source: Cosmetic Science
Expert Verdict
✅ None significant. Well-established, naturally occurring amino acid with excellent safety history.
Regulatory Flags
Frequently Asked Questions
Is Proline safe in cosmetics?
✅ None significant. Well-established, naturally occurring amino acid with excellent safety history. The EU classifies Proline as "permitted". Safety rating: EXCELLENT.
Is Proline allowed in the EU?
Proline EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Proline do in cosmetics?
Proline functions as: Skin conditioning, hair conditioning, buffering/pH stabilizer, moisturizing (NMF component). It is classified as a cosmetic ingredient in our database. CAS number: 147-85-3 (L-Proline); 609-36-9 (DL-Proline).
What is the Margin of Safety for Proline?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
Check Proline compliance across multiple jurisdictions:
Related Ingredients
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