Propylenediamine

INCI: PROPYLENEDIAMINE

CAS Number
78-90-0 (1,2-diaminopropane)
Function
Chelating, Buffering
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Limited cosmetic use; no specific CIR monograph; GHS classified as corrosive/irritant

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

๐Ÿšจ CRITICAL: GHS H314 (Corrosive), H302 (Acute Toxicity Cat 4), H317 (Skin Sensitizer); cross-reacts with ethylenediamine; strictly limit concentration or avoid entirely; SCCS review mandatory before formulation use

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Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Propylenediamine safe in cosmetics?

๐Ÿšจ CRITICAL: GHS H314 (Corrosive), H302 (Acute Toxicity Cat 4), H317 (Skin Sensitizer); cross-reacts with ethylenediamine; strictly limit concentration or avoid entirely; SCCS review mandatory before formulation use The EU classifies Propylenediamine as "restricted". Safety rating: POOR.

Is Propylenediamine allowed in the EU?

Propylenediamine EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Propylenediamine do in cosmetics?

Propylenediamine functions as: Chelating, Buffering. It is classified as a cosmetic ingredient in our database. CAS number: 78-90-0 (1,2-diaminopropane).

What is the Margin of Safety for Propylenediamine?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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