Is Propylenediamine safe in cosmetics?
Propylenediamine has a safety rating of "POOR" in our database. EU status: restricted. US status: permitted.
POOR
Cosmetic Ingredient
Propylenediamine
INCI: PROPYLENEDIAMINE
Propylenediamine (CAS 78-90-0 (1,2-diaminopropane)) is a cosmetic cosmetic ingredient functioning as Chelating, Buffering. EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 78-90-0 (1,2-diaminopropane) →
Function
Chelating, Buffering
Editorial assessment
POOR
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Limited cosmetic use; no specific CIR monograph; GHS classified as corrosive/irritant
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Propylenediamine.
Calculate MoS for your specific formulation with the MoS Calculator.
Editorial summary
Preliminary editorial summary for Propylenediamine — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
potential-allergen
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Propylenediamine by CAS number or substance name.
Studies
3
Lowest NOAEL
250 mg/kg bw/day
Highest NOAEL
250 mg/kg bw/day
ECHA
Frequently Asked Questions
Is Propylenediamine allowed in the EU?
Propylenediamine EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Propylenediamine do in cosmetics?
Propylenediamine functions as: Chelating, Buffering. It is classified as a cosmetic ingredient in our database. CAS number: 78-90-0 (1,2-diaminopropane).
Compliance Tools
Check Propylenediamine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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2-METHYLPROPANOL
GOOD
Chemical family
Perfuming
2-Methylpropanal
MODERATE
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Fragrance; Nail Conditioning
2-Methylpropanol (Isobutanol)
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