Protodioscin

INCI: PROTODIOSCIN

CAS Number
55056-80-9
Function
Skin conditioning (steroidal saponin from *Tribulus terrestris*)
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not specifically listed for cosmetic use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

๐Ÿ”ด Steroidal saponin โ€” demonstrated biological activity including nitric oxide release ; potential endocrine-active compound. No CosIng registration as standalone ingredient. Using as isolated compound requires full safety dossier. Hormonal activity concern for EU SCCS review.

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Concern Level: High

Frequently Asked Questions

Is Protodioscin safe in cosmetics?

๐Ÿ”ด Steroidal saponin โ€” demonstrated biological activity including nitric oxide release ; potential endocrine-active compound. No CosIng registration as standalone ingredient. Using as isolated compound requires full safety dossier. Hormonal activity concern for EU SCCS review. The EU classifies Protodioscin as "permitted". Safety rating: POOR.

Is Protodioscin allowed in the EU?

Protodioscin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Protodioscin do in cosmetics?

Protodioscin functions as: Skin conditioning (steroidal saponin from *Tribulus terrestris*). It is classified as a cosmetic ingredient in our database. CAS number: 55056-80-9.

What is the Margin of Safety for Protodioscin?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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