Good Fragrance Dermal Penetration

Pycnogenol (Pinus Pinaster Bark Extract)

INCI: PYCNOGENOL

CAS Number
90082-75-0
Function
Antioxidant
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Recognized only titanium dioxide and zinc oxide as permitted mineral sunscreens.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Dermal Penetration Profile

Skin absorption and penetration characteristics of Pycnogenol (Pinus Pinaster Bark Extract), relevant to systemic exposure and MoS calculations.

Absorption %
6-12%
Penetration Level
epidermis
Penetration Depth
epidermis
Molecular Weight
Variable Da
Log P
n/a
Systemic Absorption
minimal
Topical Bioavailability
4-10%
Safety Margin Factor
moderate
Vehicle Dependent
Yes โ€” absorption varies by formulation

Source: Clin Cosmet Investig Dermatol 2012

Expert Verdict

Good safety profile with antioxidant benefits; generally considered safe for cosmetic use.

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Concern Level: Low

Regulatory Flags

eu_cosing_listed

Frequently Asked Questions

Is Pycnogenol (Pinus Pinaster Bark Extract) safe in cosmetics?

Good safety profile with antioxidant benefits; generally considered safe for cosmetic use. The EU classifies Pycnogenol (Pinus Pinaster Bark Extract) as "permitted". Safety rating: GOOD.

Is Pycnogenol (Pinus Pinaster Bark Extract) allowed in the EU?

Pycnogenol (Pinus Pinaster Bark Extract) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Pycnogenol (Pinus Pinaster Bark Extract) do in cosmetics?

Pycnogenol (Pinus Pinaster Bark Extract) functions as: Antioxidant. It is classified as a Fragrance in our database. CAS number: 90082-75-0.

What is the Margin of Safety for Pycnogenol (Pinus Pinaster Bark Extract)?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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