SH-DS Phosphorothioate RNA-2 Cholesterol
INCI: SH-DS PHOSPHOROTHIOATE RNA-2 CHOLESTEROL
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
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Expert Verdict
🔴 Critical flags: (1) Cholesterol conjugation enhances cellular internalization by design . (2) Phosphorothioate modification increases nuclease resistance and tissue half-life . (3) Double-stranded RNA can trigger RNAi gene-silencing machinery. (4) Claims must be scrutinized — any gene expression modulation claims = drug. (5) No CIR review. (6) Unprecedented complexity for a cosmetic ingredient. Requires full supplier dossier with off-target silencing data, cytotoxicity, and immunogenicity t...
Frequently Asked Questions
Is SH-DS Phosphorothioate RNA-2 Cholesterol safe in cosmetics?
🔴 Critical flags: (1) Cholesterol conjugation enhances cellular internalization by design . (2) Phosphorothioate modification increases nuclease resistance and tissue half-life . (3) Double-stranded RNA can trigger RNAi gene-silencing machinery. (4) Claims must be scrutinized — any gene expression modulation claims = drug. (5) No CIR review. (6) Unprecedented complexity for a cosmetic ingredient. Requires full supplier dossier with off-target silencing data, cytotoxicity, and immunogenicity t... The EU classifies SH-DS Phosphorothioate RNA-2 Cholesterol as "permitted". Safety rating: POOR.
Is SH-DS Phosphorothioate RNA-2 Cholesterol allowed in the EU?
SH-DS Phosphorothioate RNA-2 Cholesterol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does SH-DS Phosphorothioate RNA-2 Cholesterol do in cosmetics?
SH-DS Phosphorothioate RNA-2 Cholesterol functions as: Skin conditioning / hair conditioning; double-stranded phosphorothioate-modified RNA conjugated to cholesterol — functionally an siRNA-type construct. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned / not publicly listed.
What is the Margin of Safety for SH-DS Phosphorothioate RNA-2 Cholesterol?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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