Is SH-DS Phosphorothioate RNA-2 Cholesterol safe in cosmetics?
SH-DS Phosphorothioate RNA-2 Cholesterol has a safety rating of "POOR" in our database. EU status: permitted. US status: permitted.
Poor
Cosmetic Ingredient
SH-DS Phosphorothioate RNA-2 Cholesterol
INCI: SH-DS PHOSPHOROTHIOATE RNA-2 CHOLESTEROL
SH-DS Phosphorothioate RNA-2 Cholesterol (CAS Not assigned / not publicly listed) is a cosmetic cosmetic ingredient functioning as Skin conditioning / hair conditioning; double-stranded. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS Not assigned / not publicly listed →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning / hair conditioning; double-stranded phosphorothioate-modified RNA conjugated to cholesterol — functionally an siRNA-type construct
Safety Rating
POOR
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No specific cosmetic restriction, but high regulatory risk — phosphorothioate siRNA-cholesterol conjugates are pharmacologically active gene-silencing molecules
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for SH-DS Phosphorothioate RNA-2 Cholesterol.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for SH-DS Phosphorothioate RNA-2 Cholesterol.
Frequently Asked Questions
Is SH-DS Phosphorothioate RNA-2 Cholesterol allowed in the EU?
SH-DS Phosphorothioate RNA-2 Cholesterol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does SH-DS Phosphorothioate RNA-2 Cholesterol do in cosmetics?
SH-DS Phosphorothioate RNA-2 Cholesterol functions as: Skin conditioning / hair conditioning; double-stranded phosphorothioate-modified RNA conjugated to cholesterol — functionally an siRNA-type construct. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned / not publicly listed.
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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