Excellent Surfactant NOAEL Data

Sodium Cocoyl Glutamate

INCI: SODIUM COCOYL GLUTAMATE

CAS Number
68187-32-6
Function
Surfactant; primary cleanser; foam booster
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Amino acid-based surfactant; not individually CIR reviewed but broadly used in premium facial cleansers. COSMOS/ECOCERT certified. Optimal pH 5.0โ€“6.0 aligns with skin acid mantle. OECD 301B biodegradability >60% in 28 days.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

4 study endpoints found for Sodium Cocoyl Glutamate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL ca.1200 mg/kg bw/day oral rat oral REACH
NOAEL ca.1200 mg/kg bw/day oral - oral REACH
NOAEL ca.1200 mg/kg bw/day oral rat oral REACH
NOAEL ca.1200 mg/kg bw/day oral - oral REACH

Expert Verdict

The mildest anionic surfactant class available. Glutamic acid-derived, coconut-based. Optimal pH 5.0โ€“6.0 perfectly aligns with the skin's natural acid mantle, minimizing protein denaturation and ceramide extraction. Produces moderate, creamy foam appreciated in premium facial cleanser positioning. COSMOS/ECOCERT certifiable. OECD 301B biodegradability >60% in 28 days. First-choice anionic for sensitive, atopic, and pediatric formulations.

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Concern Level: None

Regulatory Flags

amino-acid-surfactant sulfate-free ecocert cosmos biodegradable mildest-anionic atopic-safe eu_children_restricted epa_safer_alternative

Frequently Asked Questions

Is Sodium Cocoyl Glutamate safe in cosmetics?

The mildest anionic surfactant class available. Glutamic acid-derived, coconut-based. Optimal pH 5.0โ€“6.0 perfectly aligns with the skin's natural acid mantle, minimizing protein denaturation and ceramide extraction. Produces moderate, creamy foam appreciated in premium facial cleanser positioning. COSMOS/ECOCERT certifiable. OECD 301B biodegradability >60% in 28 days. First-choice anionic for sensitive, atopic, and pediatric formulations. The EU classifies Sodium Cocoyl Glutamate as "permitted". Safety rating: EXCELLENT. 4 toxicological study endpoint(s) are available in our database.

Is Sodium Cocoyl Glutamate allowed in the EU?

Sodium Cocoyl Glutamate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Sodium Cocoyl Glutamate do in cosmetics?

Sodium Cocoyl Glutamate functions as: Surfactant; primary cleanser; foam booster. It is classified as a Surfactant in our database. CAS number: 68187-32-6.

What is the Margin of Safety for Sodium Cocoyl Glutamate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Sodium Cocoyl Glutamate?

The NOAEL (No Observed Adverse Effect Level) for Sodium Cocoyl Glutamate is ca.1200 mg/kg bw/day based on a oral study via oral route in rat. A total of 4 study endpoints are available. Source: REACH.

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