Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for Sodium Fluoride. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | ca.25 ppm | oral | rat | oral | REACH |
| LOAEL | ca.4 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | ca.100 ppm | oral | rat | oral | REACH |
| LOAEL | ca.50 ppm | oral | mouse | oral | REACH |
| LOAEL | ca.25 ppm | oral | rat | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Sodium Fluoride is a restricted ingredient in the EU with concentration limits for oral care use; permitted in the US with established safety guidelines for cosmetic applications.
Regulatory Flags
Frequently Asked Questions
Is Sodium Fluoride safe in cosmetics?
Sodium Fluoride is a restricted ingredient in the EU with concentration limits for oral care use; permitted in the US with established safety guidelines for cosmetic applications. The EU classifies Sodium Fluoride as "restricted". Safety rating: MODERATE. 5 toxicological study endpoint(s) are available in our database.
Is Sodium Fluoride allowed in the EU?
Sodium Fluoride EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium Fluoride do in cosmetics?
Sodium Fluoride functions as: antiplaque agent and oral care ingredient in cosmetic products. It is classified as a Cosmetic Ingredient in our database. CAS number: 7681-49-4.
What is the Margin of Safety for Sodium Fluoride?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Sodium Fluoride?
The NOAEL (No Observed Adverse Effect Level) for Sodium Fluoride is ca.25 ppm based on a oral study via oral route in rat. A total of 5 study endpoints are available. Source: REACH.
Compliance Tools
Check Sodium Fluoride compliance across multiple jurisdictions:
Related Ingredients
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