Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Squalane. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | ca.10000 mg/kg bw/day | oral | rat | oral | REACH |
Dermal Penetration Profile
Skin absorption and penetration characteristics of Squalane, relevant to systemic exposure and MoS calculations.
Source: Cosmetic Science
Expert Verdict
CIR confirmed Squalane safe in current practices of use up to 96.8%. Hydrogenated form of Squalene (CAS 111-01-3) is fully saturated and non-oxidizable with no peroxide formation risk. No EU source restriction. No genotoxicity or carcinogenicity concerns. Ideal leave-on emollient.
Regulatory Flags
Frequently Asked Questions
Is Squalane safe in cosmetics?
CIR confirmed Squalane safe in current practices of use up to 96.8%. Hydrogenated form of Squalene (CAS 111-01-3) is fully saturated and non-oxidizable with no peroxide formation risk. No EU source restriction. No genotoxicity or carcinogenicity concerns. Ideal leave-on emollient. The EU classifies Squalane as "permitted". Safety rating: EXCELLENT. 1 toxicological study endpoint(s) are available in our database.
Is Squalane allowed in the EU?
Squalane EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Squalane do in cosmetics?
Squalane functions as: emollient, skin-conditioning, spreading agent. It is classified as a Emollient in our database. CAS number: 111-01-3.
What is the Margin of Safety for Squalane?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Squalane?
The NOAEL (No Observed Adverse Effect Level) for Squalane is ca.10000 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.
Compliance Tools
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Related Ingredients
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