Stephania Tetrandra Root Extract

INCI: STEPHANIA TETRANDRA ROOT EXTRACT

CAS Number
223748-82-1
Function
Skin Conditioning
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status restricted
US Notes Not specifically restricted; permitted for cosmetic use under general provisions

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

CRITICAL: Historically confused with *Aristolochia fangchi* (contains nephrotoxic/carcinogenic aristolochic acids). Reported liver and kidney toxicity even from authentic material. Requires verified botanical authentication and AA-free certification

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Concern Level: High

Regulatory Flags

plant-extract natural-origin

Frequently Asked Questions

Is Stephania Tetrandra Root Extract safe in cosmetics?

CRITICAL: Historically confused with *Aristolochia fangchi* (contains nephrotoxic/carcinogenic aristolochic acids). Reported liver and kidney toxicity even from authentic material. Requires verified botanical authentication and AA-free certification The EU classifies Stephania Tetrandra Root Extract as "permitted". Safety rating: POOR.

Is Stephania Tetrandra Root Extract allowed in the EU?

Stephania Tetrandra Root Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Stephania Tetrandra Root Extract do in cosmetics?

Stephania Tetrandra Root Extract functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 223748-82-1.

What is the Margin of Safety for Stephania Tetrandra Root Extract?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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