Regulatory Status
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Safety Data
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Expert Verdict
Preventive enzymatic antioxidant that intercepts superoxide radicals before chain initiation, mechanistically complementary to chain-breaking antioxidants. Typical use 0.001–0.01% active protein. Critical formulation challenge: protein stability and penetration require liposomal delivery with unsaturated phosphatidylcholine-based liposomes. Conventional aqueous formulations rapidly inactive. Claims require substantiation with stability and penetration data. Recombinant or plant-derived SOD preferred over bovine-source. Best suited to premium anti-pollution and anti-aging formulations with appropriate delivery technology.
Regulatory Flags
Frequently Asked Questions
Is Superoxide Dismutase safe in cosmetics?
Preventive enzymatic antioxidant that intercepts superoxide radicals before chain initiation, mechanistically complementary to chain-breaking antioxidants. Typical use 0.001–0.01% active protein. Critical formulation challenge: protein stability and penetration require liposomal delivery with unsaturated phosphatidylcholine-based liposomes. Conventional aqueous formulations rapidly inactive. Claims require substantiation with stability and penetration data. Recombinant or plant-derived SOD preferred over bovine-source. Best suited to premium anti-pollution and anti-aging formulations with appropriate delivery technology. The EU classifies Superoxide Dismutase as "permitted". Safety rating: EXCELLENT.
Is Superoxide Dismutase allowed in the EU?
Superoxide Dismutase EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Superoxide Dismutase do in cosmetics?
Superoxide Dismutase functions as: Enzymatic antioxidant; preventive antioxidant; converts superoxide radicals (O2•−) to hydrogen peroxide at the radical initiation stage; anti-pollution active. It is classified as a Antioxidant in our database. CAS number: 9054-89-1.
What is the Margin of Safety for Superoxide Dismutase?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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