Is Superoxide Dismutase safe in cosmetics?
Superoxide Dismutase has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Antioxidant
Superoxide Dismutase
Also known as: Dismutase, superoxide, Copper-zinc superoxide dismutase, Cu/Zn-Superoxide dismutase, Superoxide dismutase, copper-zinc
INCI: SUPEROXIDE DISMUTASE
Superoxide Dismutase (CAS 9054-89-1) is a cosmetic antioxidant functioning as Enzymatic antioxidant; preventive antioxidant; converts superoxide radicals. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in food safety data.
View industrial chemical safety profile for CAS 9054-89-1 →
Auto-generated CPSR Part A draft with source citations
Function
Enzymatic antioxidant; preventive antioxidant; converts superoxide radicals (O2•−) to hydrogen peroxide at the radical initiation stage; anti-pollution active
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No FDA restrictions for topical cosmetic use. Classified as cosmetic ingredient. No specific CIR final report. FDA recognises catalase and SOD as GRAS for food enzyme preparations (21 CFR 184). Bovine-source SOD historically used — recombinant and plant-derived forms now preferred for BSE risk mitigation.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Superoxide Dismutase.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
3 property records from structured ingredient metadata.
baby_pediatric
{"cas_number": "CAS-FUNC-34", "ingredient_class": "other", "pediatric_safety_rating": "good", "minimum_age_months": "3", "neonatal_safe": "no", "premature_infant_safe": "insufficient_data", "skin_barrier_maturity_consideration": "Functional ingredient - generally safe", "transepidermal_absorption_risk_pediatric": "low", "systemic_exposure_concern_pediatric": "low", "dose_per_kg_body_weight_concern…
synergy
{"inci_name_2": "Catalase + Glutathione Peroxidase", "synergy_type": "antioxidant-synergy", "synergy_description": "Triple antioxidant enzyme system for complete ROS defense", "combined_benefit": "Complete reactive oxygen species neutralization, enzymatic protection cascade", "efficacy_multiplier": "3.5x", "mechanism_of_action": "SOD converts superoxide to H2O2; catalase/GPx convert H2O2 to water …
uv_stability
{"uv_stable": "partially", "uv_degradation_rate": "moderate", "photosensitizer": "no", "phototoxic": "no", "photoallergic": "no", "requires_uv_protection_packaging": "yes", "color_change_uv": "no", "odor_change_uv": "no", "efficacy_loss_uv_pct": "25", "spf_contribution": "no", "uva_protection": "no", "uvb_protection": "no", "photostable_sunscreen": "no", "boost_spf_of_others": "no", "antioxidant_u…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Reducing agent
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Superoxide Dismutase.
Regulatory Flags
antioxidant
enzymatic
preventive-antioxidant
protein
encapsulation-required
liposomal-delivery
stability-challenge
penetration-challenge
anti-pollution
endogenous-enzyme
high-molecular-weight
Known Synonyms
Dismutase, superoxide
Copper-zinc superoxide dismutase
Cu/Zn-Superoxide dismutase
Superoxide dismutase, copper-zinc
Chemical Function
Antioxidant
Softener and conditioner
Reducing agent
Regulatory Lists
Canada
consumer_product
Substances in Products - Canada (4/2014)
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Superoxide dismutase
Food Category
preservative
Frequently Asked Questions
Is Superoxide Dismutase allowed in the EU?
Superoxide Dismutase EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Superoxide Dismutase do in cosmetics?
Superoxide Dismutase functions as: Enzymatic antioxidant; preventive antioxidant; converts superoxide radicals (O2•−) to hydrogen peroxide at the radical initiation stage; anti-pollution active. It is classified as a Antioxidant in our database. CAS number: 9054-89-1.
Is Superoxide Dismutase used outside cosmetics?
Superoxide Dismutase also appears in food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Superoxide Dismutase compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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