Is Tripeptide-10 Citrulline (Decorinyl®) safe in cosmetics?
Tripeptide-10 Citrulline (Decorinyl®) has a safety rating of "MODERATE" in our database. EU status: permitted. US status: restricted.
Moderate
Active Ingredient
Tripeptide-10 Citrulline (Decorinyl®)
INCI: TRIPEPTIDE-10 CITRULLINE
Tripeptide-10 Citrulline (Decorinyl®) (CAS 960531-53-7) is a cosmetic active ingredient functioning as Peptide / Anti-aging active. EU Regulation 1223/2009 status: permitted, max 54%. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 960531-53-7 →
Auto-generated CPSR Part A draft with source citations
Function
Peptide / Anti-aging active
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
(3S)-4-[[(2S,3S)-1-[[(2S)-1-amino-5-(carbamoylamino)-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-[[(2S)-2,6-diaminohexanoyl]amino]-4-oxobutanoic acid
InChIKey
GKPMARPRXONRJX-BWJWTDLKSA-N
Regulatory Status
EU EU Status
permitted
EU Max Conc.
54%
US US Status
restricted
US Notes
OTC drug classification; no specific concentration restrictions.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tripeptide-10 Citrulline (Decorinyl®).
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
5 property records from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "firming, collagen-boosting", "mechanism_of_action": "Signal peptide for fibroblast activation", "target_skin_layer": "dermis", "collagen_stimulation": "Yes", "elastin_protection": "Moderate", "wrinkle_reduction_pct": "15-23", "clinical_study_duration_weeks": "8", "sample_size": "25", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal": "JOCD, Int J Pept Re…
anti_pollution
{"cas_number": "949287-68-5", "ingredient_class": "other", "primary_mechanism": "barrier_reinforcement", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_kB_inhibi…
peptide
{"cas_number": "960531-53-7", "trade_name": "Decorinyl", "peptide_sequence_amino_acids": "Gly-Hyp-Citrulline", "peptide_length_residues": "3", "molecular_weight_daltons": "342.3", "peptide_class": "signal", "mechanism_of_action": "Mimics decorin to regulate collagen fibrillogenesis, improves collagen organization", "target_protein_or_receptor": "Decorin receptor/TGF-beta modulation", "biomimetic_o…
synergy
{"inci_name_2": "Hyaluronic Acid", "synergy_type": "efficacy-boost", "synergy_description": "Collagen-organizing peptide with hydration for dermal structure", "combined_benefit": "Improved collagen organization, enhanced hydration, better skin architecture", "efficacy_multiplier": "2x", "mechanism_of_action": "Tripeptide-10 improves collagen fibril organization; HA provides hydration", "optimal_ra…
uv_stability
{"uv_stable": "yes", "uv_degradation_rate": "stable", "photosensitizer": "no", "phototoxic": "no", "photoallergic": "no", "requires_uv_protection_packaging": "no", "color_change_uv": "no", "odor_change_uv": "no", "efficacy_loss_uv_pct": "5", "spf_contribution": "no", "uva_protection": "no", "uvb_protection": "no", "photostable_sunscreen": "no", "boost_spf_of_others": "no", "antioxidant_under_uv": …
Expert Verdict
Expert safety assessment and concern-level summary for Tripeptide-10 Citrulline (Decorinyl®).
Frequently Asked Questions
Is Tripeptide-10 Citrulline (Decorinyl®) allowed in the EU?
Tripeptide-10 Citrulline (Decorinyl®) EU regulatory status: permitted. Maximum allowed concentration: 54%. This is based on EU Regulation 1223/2009 and its amendments.
What does Tripeptide-10 Citrulline (Decorinyl®) do in cosmetics?
Tripeptide-10 Citrulline (Decorinyl®) functions as: Peptide / Anti-aging active. It is classified as a Active Ingredient in our database. CAS number: 960531-53-7.
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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